Renewal of the Network of Hubs for Trials Methodology Research.

随着对可用于医疗保健的资源的需求不断增加，包括从业者、患者、政策制定者和公众在内的决策者能够获得可靠和可靠的信息，了解他们可能选择的不同干预措施的相对效果，这一点变得越来越重要。这些信息主要来自比较干预措施的临床试验，试验本身需要以有效和有效的方式进行。2009年，MRC建立了试验方法研究中心，以进行研究以实现这一目标，并促进将这项研究的结果在试验中付诸实践。建立了一个网络，以增加各个中心的工作的价值，这项提议寻求将网络的工作再延长五年，并将工作范围扩大到包括一项培训方案，该方案将为今后的方法研究建设能力。这将通过一个独特的试验方法学博士研究生项目来实现，这将在该领域培养新的专家。这些中心提供了一个英国范围内、地区分布的研究资源，以改进临床试验的设计、进行、分析、解释和报告。该网络将各中心联系起来，以加强它们的个人活动，进一步加强方法学研究，并改进与临床试验中良好方法有关的传播和教育。该网络为高度优先的研究提供资金，以回答围绕试验的具体问题；举办研讨会以开发方法并培训参与试验的人员；每两年组织一次大型国际会议，将研究人员聚集在一起，分享他们目前的研究并相互学习；并将建立和实施一项新的计划，供博士生在全国方法学研究计划中培训为方法学家。该网络帮助中心与许多对英国和国际临床试验至关重要的个人和组织合作。这些人包括资助试验的人，如国家健康研究所和主要慈善机构，包括英国癌症研究所、英国关节炎和英国心脏基金会；组织试验的人，包括制药业和大学；支持试验的团体，包括在英国注册的临床试验单位、研究设计服务和私营部门的合同研究组织；以及医疗保健用户和在学术界、实践界和工业界开展试验的个人。根据这一建议，该网络将继续实现其四个主要目标，并增加与博士生名额有关的第五个目标。这些目标是：a)促进高质量的协作方法学研究，包括跨中心和与其他组织、英国范围和国际合作。b)向临床试验社区提供方法学建议。c)鼓励实施最有效和最适当的方法学实践，例如通过提供协调的一揽子教育和培训。D)与外部利益攸关方合作，特别是就研究和指导的共同优先事项达成一致。e)通过支持一批临床和非临床博士生的方法学在英国进行培训的能力建设。该网络对这一学生计划的协调将：&>培养一支拥有使他们处于试验方法学发展前沿的技能的科学家队伍。使博士生与网络的战略目标和研究优先事项保持一致，同时反映学生所在中心的优先事项。&>；为学生提供独特的跨学科和多样化的分析和技术技能培训。在网络中发展和维持充满活力的研究生文化。提高学生计划的知名度，以吸引优秀的候选人。

With the rising demands on the resources available for health care, it is increasingly important that decision makers, including practitioners, patients, policy makers and the public, have access to reliable and robust information about the relative effects of different interventions they might choose between. This information primarily comes from clinical trials which compared the interventions, and trials themselves need to be conducted in ways that are efficient and effective. In 2009, the MRC established the Hubs for Trials Methodology Research to conduct research to achieve this, and to facilitate the implementation of the findings of this research into practice in trials. A Network was created to add value to the work of the individual Hubs and this proposal seeks to renew the work of the Network for five more years and to extend the work to include a programme of training that will build capacity in methodology research for the future. This will be achieved by a unique programme of PhD studentships in trial methodology, which will create new experts in this area.The Hubs provide a UK-wide, regionally distributed research resource to improve the design, conduct, analysis, interpretation, and reporting of clinical trials. The Network links the Hubs to enhance their individual activities, strengthen the methodological research further, and improve dissemination and education relating to good methods in clinical trials. The Network provides funds for high priority research to answer specific issues around trials; conducts workshops to develop methods and train people involved in trials; organises a large international conference every two years to bring researchers together to share their current research and learn from each other; and, will establish and implement a new programme for PhD students to train as methodologists within a national programme of methodology research.The Network helps the Hubs to work with many people and organisations who are key to clinical trials in the UK and internationally. These include those who fund trials, such as the National Institute for Health Research and major charities including Cancer Research UK, Arthritis UK and the British Heart Foundation; those who organise trials, including the pharmaceutical industry and universities; the groups that support them, including the UK-registered Clinical Trials Units, Research Design Services and Contract Research Organisations in the private sector; as well as the users of health care and individuals who run trials in academia, practice and industry. Under this proposal, the Network will continue with its four main objectives and add a fifth relating to the PhD studentships. These objectives are:a) Promoting high quality collaborative methodological research, both across Hubs and with other groups, UK-wide and internationally.b) Providing methodological advice to the clinical trials community.c) Encouraging the implementation of the most effective and appropriate methodological practice, for example by providing a coordinated package of education and training. d) Working with external stakeholders, in particular to agree on shared priorities for research and guidance.e) Capacity building of training in the UK by supporting a cohort of clinical and non-clinical PhD students in methodology.The coordination of this studentship programme by the Network will:> Create a cadre of scientists, including clinicians, with skills that will place them at the forefront of trials methodology development.> Align the PhD studentships with the Network's strategic aims and research priorities, while reflecting the priorities of the Hub in which the student is based.> Offer students unique inter-disciplinary and diverse analytical and technical skill training.> Develop and sustain a vibrant postgraduate student culture in the Network.> Raise the profile of the studentship programme, to attract outstanding candidates.