PILOT STUDY TO EVALUATE SAFETY & TOLERABILITY OF LOSARTAN W/ENALAPRIL

本研究调查了氯沙坦的安全性和耐受性 与依那普利的常规剂量（10 mg BID）同时给药， 接受治疗的NYHA心功能III至IV级心力衰竭患者 之前使用ACE抑制剂。 此外，为了调查 氯沙坦三种治疗方案的疗效比较 在常规剂量依那普利和高剂量依那普利的基础上， 运动耐量、神经激素激活和生活质量。

This study investigates the safety and tolerability of losartan administered concurrently with the usual dose (10mg BID) of enalapril in patients with NYHA Functional Class III to IV heart failure treated previously with an ACE inhibitor. Additionally, to investigate the effects of the three treatment regimens of losartan administered in addition to usual dose enalapril and high dose enalapril on submaximal exercise tolerance, neurohormone activation and quality of life.