Developing novel peptide-based therapeutics and technologies to mitigate fibrosis

纤维化（组织瘢痕）是一个未解决的医学问题，对人类健康和医疗设备都有不利影响。它会导致器官（如心脏、肾脏）衰竭，导致死亡。纤维性包封导致医疗器械（如外科补片）失效。我们的团队发现了一种肽，B7-33，可以在短期内减轻纤维化。我们的IDEAS资助旨在开发长效B7-33疗法，并将长效B7-33模拟物应用于外科补片的抗纤维化组合物中。

Fibrosis (tissue scarring) is an unmet medical problem that adversely affects both human health and medical devices. It causes organ (e.g. heart, kidney) failure leading to death. Fibrotic encapsulation causes medical device (e.g. surgical mesh) failure. Our team has discovered a peptide, B7-33, that mitigates fibrosis in the short-term. Our IDEAS grant aims to develop long-acting B7-33 therapies and, to employ long-acting B7-33 mimetics in anti-fibrotic compositions for surgical meshes.