Contribution of Neuro-inflammation to Cerebral Ischaemia

炎症是我们身体对感染和损伤的反应。它的特点是发红、肿胀和发热，需要从血液中招募细胞到感染或受伤区域。通常炎症是一种有益的反应。然而，未能关闭炎症反应或使其消退，可能导致慢性或不适当的炎症。这会导致健康细胞和组织的死亡。随着年龄的增长，身体对炎症的控制能力开始减弱。因此，当我们的身体受到伤害或感染的挑战时，它们无法有效地应对。针对多种器官的感染和损伤，对炎症的机制进行了大量的研究，并取得了很大的进展。然而，炎症是如何在大脑中调节的，研究得很少，我们目前还不知道这些反应是如何协调的。这项提议的主要目的是了解大脑中炎症的调节。我们可以接触到炎症反应的特定部分被移除或去除的老鼠。利用这些老鼠，我们可以检查脑损伤后的炎症反应，比如中风。这将为我们提供有关发生的具体反应及其后果的信息。脑部炎症对人们的健康和福祉有重大影响，对老年人尤其如此。因此，了解大脑如何调节炎症可能会导致治疗脑损伤和疾病的新策略。

Inflammation is our bodies' response to infection and injury. It is characterised by redness, swelling, and heat and requires recruitment of cells from the blood to an infected or injured area. Typically inflammation is a beneficial response. However, a failure to switch off an inflammatory response, or for it to resolve, can lead to chronic or inappropriate inflammation. This can result in the death of healthy cells and tissue. As we age the bodies control of how it regulates inflammation begins to diminish. Therefore when our bodies are challenged by an injury or an infection they fail to cope efficiently. Much research on mechanisms of inflammation has been carried out with respect to many types of infection and injury in many organs and great progress has been made. However, how inflammation is regulated in the brain is far less studied and we do not currently understand how the responses are coordinated. The main aim of this proposal is to understand the regulation of inflammation in the brain. We have access to mice in which specific parts of the inflammatory response have been removed, or knocked out. Using these mice we can examine the inflammatory response in the brain after an injury such as caused by stroke. This will give us information on the specific reactions that occur and their consequence. Brain inflammation has a significant impact on the health and wellbeing of the population, and particularly so for people of old age. Thus understanding how the brain regulates inflammation could lead to new strategies to treat brain injury and disease.