SUBPOPULATIONS OF MOTOR CORTICAL NEURONS IN LOCOMOTION

运动皮层网络中神经元的特性已经产生了 由于运动皮层和大脑皮层之间的直接联系， 激活和运动行为。锥体束神经元最多 运动皮层中众所周知的元素。然而，人们对 其他主要运动皮质传出通路与 神经元间类到运动行为。 这项工作的主要目标是研究的关系， 运动皮层网络内的识别元件（传出和 interneuronal亚群）到运动行为。特别注意 将被给予大量的“沉默”神经元， 在清醒但不动的受试者的传出神经元中描述。 所有数据将从经过训练的兔子中获得， 实验室在平坦的水平面上，上坡和下坡， 一种斜坡，两个前肢上都有重物， 不同形状的障碍物。 这些数据将为运动皮层的生理学提供一个独特的视角 网络研究在自然条件下的自由行为的动物。 这种对运动皮层内已识别亚群的分析， 没有在任何物种中进行过。

The properties of neurons in the motor cortical networks have generated considerable attention because of the direct link between motor cortical activation and motor behavior. The pyramidal tract neurons are the most well-known elements of the motor cortex. However, little is known about the relationship of other major motor cortical efferent pathways and interneuronal classes to motor behavior. The primary goal of this work is to examine the relationship of identified elements within the motor cortical networks (efferent and interneuronal subpopulations) to locomotor behavior. A special attention will be given to a large population of 'silent" neurons that have been described among efferent neurons in awake but immobilized subjects. All data will be obtained from rabbits trained to walk inside an experimental chamber on a flat horizontal surface, uphill and downhill on an incline, with weights attached to both forelimbs and overcoming obstacles of different shapes. The data will offer a unique view on the physiology of the motor cortical network studied under natural conditions of a freely behaving animal. Such an analysis of identified subpopulations within the motor cortex has not been performed in any species.