BRAIN/GUT AXIS--METHODS TO EXAMINE PEPTIDE DYNAMICS

神经肽是化学信使，其在中枢神经系统中的功能尚不清楚。 神经肽的生理功能的理解将大大增强的方法，允许敏感的，本地分析的多个肽系统在一个显着的时间过程。 这些信息，与经典的（胺，氨基酸）神经调质系统的数据一起，可以提供关键信息的化学信使作用于DVC的相互作用的影响。 了解肽的功能及其与胺能系统的相互作用提供了神经生理学模板，以了解与大脑系统（情绪激动，冷暴露，手术，创伤，败血症，烧伤和功能性肠病）相关的胃肠道病变，并可能影响未来的治疗策略。研究人员未来的目标包括将匹兹堡小组学到的技术应用于有意识的动物模型的研究，其中可以研究行为影响。 在相邻的实验室（Dr. Joe Travers-Ohio State）常规进行慢性留置骨髓记录阵列的植入。 使微透析技术适应这些优雅的模型是一个研究目标。

Neuropeptides are chemical messengers whose function in the CNS remain unclear. The understanding of physiologic functions of neuropeptides would be greatly augmented by methods allowing sensitive, local analysis of multiple peptide systems over a significant time course. This information, taken together with data from classical (amine, amino acid) neuromodulator systems can provide critical information regarding interactive effects of chemical messengers acting at the DVC. Understanding peptide function and their interaction with aminergic systems provides the neurophysiologic template to understanding gastrointestinal pathologies related to cerebral systems (emotional agitation, cold exposure, surgery, trauma, sepsis, burns and functional bowel disorders), and could impact future therapeutic strategies. Future aims of the investigator include the application of the technology learned with the Pittsburgh groups to the study of conscious animal models, where behavioral influences may be studied. Implantations of chronic indwelling medullary recording arrays is routinely performed in an adjoining laboratory (Dr. Joe Travers-Ohio State). Adaptation of microdialysis technology to these elegant models is a research goal.