WHOLE BODY PET SCANNER USING LGSO DETECTORS

这项拟议研究的总体目标是开发一种可优化用于全身研究的PET扫描仪，它可以在常规PET扫描仪的+时间内积累两倍的计数。使用BGO(锗酸铋)的PET扫描仪受限于FGD(氟代脱氧葡萄糖)的最大活动量(可以注射给患者而不超过最大剂量)，以及基本上所有BGO系统都以2-D模式(插入SEPTA)用于全身扫描的事实。使用NaI(Tl)的PET扫描仪具有必要的能量分辨率，以允许在没有SEPTA的情况下进行全3D模式，但由于国家能力有限，因此受到可以注入的最大量的限制。LGSO是一种新开发的闪烁体，它具有类似于BGO的高阻止能力，但同时具有相对于BGO和NaI(Tl)的高光输出和非常短的衰减时间，从而潜在地导致良好的能量分辨率和高计数能力。这项拟议的研究将克服目前PET扫描仪的局限性，允许在高分辨率和高灵敏度下进行无间隔、全3D操作的身体成像。拟议的商业应用：拟议的研究将导致开发一种PET扫描仪，该扫描仪优于现有的PET扫描仪，用于使用FDG进行常规临床全身肿瘤检查。此外，该仪器还将用于许多其他PET应用。UGM目前生产PET扫描仪，并将把这种扫描仪添加到其产品线中。

The overall goal of the proposed research is to develop a PET scanner optirnized for whole-body studies which can accumulate twice the number of counts in + the time of conventional PET scanners. PET scanners using BGO (BismuthGermanate) are limited by the maximum amount of activity of FGD (FluoroDeoxyglucose) which can be injected without exceeding the maximum dose to the patient and the fact that essentially all BGO systems are used in 2-D mode (septa inserted), for whole body scanning. PET scanners using NaI(Tl) have the necessary energy resolution in order to permit full 3-D mode without septa, but are limited by the maximum amount which can be injected due to the limited countrate capability. LGSO is a newly developed scintillator which has the high stopping power similar to BGO but at the same time has a high light output as well as a very short decay time relative to both BGO and NaI(Tl), thereby potentially resulting in both good energy resolution and high countrate capability. The proposed research will overcome the limitations of present PET scanners, by permitting septaless, full 3-D operation for body imaging at high countrates and with high sensitivity. PROPOSED COMMERCIAL APPLICATIONS: The proposed research will lead to the development of a PET scanner which is superior to existing PET scanners for routine clinical whole-body tumor surveys using FDG. In addition, the instrument will also be useful for many other PET applications. UGM currently manufactures PET scanners and will add this scanner to its product line.