CORE--COMPUTING AND DATA MANAGEMENT

核心B的目标是为以下项目提供数据库管理 基因分型/表型数据(由实验室在 西南基金会遗传学部与 外部机构)，用于临床和访谈数据(由 核心A)，以及基于这些数据的家系。核心B也 提供数据质量控制、支持应用软件、 为使用的计算机提供网络和系统管理 该项目是西南基金会的项目，并保护 项目数据的机密性和安全性。这一行动的具体目标 拟议授权期内的核心是(1)管理采购 和控制本计划项目中使用的计算机化数据，以及 维护实验室数据采集软件；(2)维护 在研究过程中收集的血液样本清单； (3)管理实验室间和(4)机构间数据和 档案传输；(5)处理实验室数据并维护 用于处理的软件；(6)构造和维护 计算机化的家谱资料；(7)质量控制 收集的数据；(8)将原始数据转换为适合于 基因分析；(9)保护数据的机密性；(10) 进一步开发和增强本计划项目中使用的软件 (十一)根据需要承担系统编程任务 维护计算机系统及其通信网络； (12)为数据和系统文件提供备份；及(13) 保护本文件中使用的计算机的完整性和安全性 计划项目。

Objectives of Core B are to provide database management for genotypic/phenotypic data (generated in laboratories at the Southwest Foundation Department of Genetics and by contract with external institutions), for clinical and interview data (generated by Core A), and for pedigrees based on these data. Core B also provides for data quality control, supports applications software, provides network and systems management for computers used by this Program Project at the Southwest Foundation, and protects the confidentiality and security of project data. Specific aims of this core during the proposed grant period are (1) to manage acquisition and control of computerized data used in this Program Project, and to maintain laboratory data acquisition software; (2) to maintain an inventory of blood samples collected in the course of the research; (3) to manage inter-laboratory and (4) inter-institutional data and file transfer; (5) to process laboratory data and to maintain the software used for processing; (6) to construct and maintain computerized pedigrees of family data; (7) to control the quality of the data collected; (8) to transform raw data into forms suitable for genetic analysis; (9) to protect the confidentiality of data; (10) to further develop and enhance software used in this Program Project as needed; (11) to undertake systems programming tasks as needed to maintain the computer system and its communications network; (12) to provide backup for data and systems files; and (13) to protect the integrity and security of the computers used in this Program Project.