SEROTONIN AND SMOKING AND PSYCHOPATHOLOGY

描述：（申请人摘要） 烟草使用在严重精神病患者中不成比例地高 精神障碍，如精神分裂症和情感障碍。 所报告的 精神分裂症患者中吸烟的流行率为74-90%， 45-75%的重度抑郁症患者，相比之下， 一般人口。 不仅烟草使用更加普遍， 吸烟的病人也更有可能大量吸烟，使用高焦油， 和尼古丁香烟，吸烟时间超过 吸烟者从普通人群。 如果严重的健康风险 在精神病人群中，吸烟是要预防的，首先是 我们需要更深入地了解为什么患者吸烟如此严重。 这项研究的目的是研究血清素参与 调节患者的精神病理症状和吸烟 患有严重的精神疾病 预测是血清素 消耗挑战将增加抑郁症和吸烟， 抑郁症患者，同时减少阴性症状和吸烟 精神分裂症患者中。 结果将提高对 吸烟的神经化学和行为过程， 设计行为和药物治疗的影响， 精神病患者的烟草依赖

DESCRIPTION: (Applicant's Abstract) Tobacco use is disproportionately high among those with severe psychiatric disorders, such as schizophrenia and affective disorders. The reported prevalence of smoking ranges from 74-90% among schizophrenic patients, to 45-75% among patients with major depression, as compared to 28% in the general population. Not only is tobacco use more prevalent, but psychiatric patients who smoke are also more likely to smoke heavily, to use high tar and nicotine cigarettes, and to have smoked for a longer period of time than smokers from the general population. If the serious health risks associated with smoking are to be prevented in the psychiatric population, it is first necessary to have a greater understanding of why patients smoke so heavily. The aim of this research is to study the involvement of serotonin in regulating psychopathologic symptoms and cigarette smoking among patients with major psychiatric disorders. The prediction is that a serotonin depletion challenge will increase depression and cigarette smoking among depressed patients, while decreasing negative symptoms and cigarette smoking among schizophrenic patients. Results will enhance understanding of the neurochemical and behavioral processes of cigarette smoking and will have implications for designing behavioral and pharmacologic treatments for tobacco dependence in psychiatric patients.