NEURONAL MIGRATION IN THE DEVELOPING BRAIN

描述（来自申请人摘要的逐字描述）： 在中枢神经系统中，在增殖区出生的神经元迁移时间长， 距离到达最终位置。这个过程对于正常的 神经系统的发育和功能。神经元迁移障碍 在大脑的异常发育和功能障碍中发挥因果作用， 双皮质综合征和癫痫大脑皮层神经元产生于 脑室区和脑室下区（SVZ）向外迁移至皮质 沿沿着胶质纤维铺片。SVZ中产生的嗅觉中间神经元前体 在前脑前部（SVZa）迁移到嗅球的“链”， 需要神经细胞粘附分子的聚唾液酸部分的方法 （NCAM）。长期目标是阐明 调节神经元迁移。目前的假设是， 嗅觉中间神经元前体和大脑皮层神经元被引导， 部分原因是一种未知的化学排斥因子为了验证这一假设， 提出了以下具体目标。具体目标1： 通过克隆候选分子gp-190，获得隔膜衍生的化学排斥因子。 具体目的2：gp-190的表征和功能分析：测定 糖蛋白-190在嗅觉中间神经元前体和嗅觉神经元分化中的作用 大脑皮层神经元这些研究将确定一个长期的指导方针， 迁移神经元的分子，并应提供进一步的了解 神经元迁移的分子机制，并有助于理解 大脑功能障碍的根本原因，如X连锁卡尔曼综合征，精神 发育迟缓和癫痫。

DESCRIPTION (Verbatim from the Applicant's Abstract): During development of the central nervous system, neurons born in proliferative zones migrate long distances to reach their final location. This process is essential for normal development and function of the nervous system. Disorders of neuronal migration play a causal role in abnormal development and dysfunction of the brain such as double cortex syndrome and epilepsy. Cerebral cortical neurons generated in the ventricular zone and subventricular zone (SVZ) migrate outward to the cortical plate along glia fibers. Olfactory interneuron precursors generated in the SVZ in the anterior forebrain (SVZa) migrate to the olfactory bulb in "chains," a process requiring the polysialic acid moiety of neural cell adhesion molecule (NCAM). The long-term goal is to elucidate the molecular mechanisms that regulate neuronal migration. The working hypothesis is that the migration of olfactory interneuron precursors and the cerebral cortical neurons is guided, in part, by an unidentified chemorepulsive factor. To test this hypothesis, the following specific aims are proposed. Specific Aim 1: Molecular cloning of the septum derived chemorepulsive factor by cloning the candidate molecule, gp-190. Specific Aim 2: Characterization and functional analysis of gp-190: Determine the role of gp-190 in the guidance of olfactory interneuron precursors and of cerebral cortical neurons. These studies would identify a long-range guidance molecule for migrating neurons and should provide further insight into molecular mechanisms of neuronal migration and contribute to the understanding of root causes of brain dysfunctions such as X-linked Kallman syndrome, mental retardation, and epilepsy.