CLUSTERING AND HYPER-LINKING OF LONG-TERM EEGS

拟议的工作为第一阶段开发的MagicMarker软件提供了增强功能。 该软件为长期EEG记录的显示和分析提供了一种新的方法。 相似活动的时期被分组为段，然后通过两遍层次聚类的状态。 这导致明显区分的背景、阵发性活动和患者状态转换。 通过超链接始终可以获得潜在的EEG，从而可以将伪影与“真实的EEG”区分开。“第二阶段的工作增加了分类能力（智能）的第一阶段的软件。 提出了专家级癫痫发作检测器、ICU异常检测器和用户定义的活动检测器。 这项工作包括开发一个大型的仔细分析和注释的长期脑电图研究图书馆。新生儿，年龄较大的儿童和成人将被包括在内，以确保所有年龄组的强大算法。拟议的软件通过对感兴趣的事件进行智能通知（可视、可听和拨号寻呼），大大减少了对工作人员进行长期监测的要求。 除了能够“远离实验室”监测患者外，这还提供了更频繁的患者检查和改善的临床结果。建议的商业应用所提出的软件将是一个有价值的除了任何数字脑电图，因为它提供了巨大的时间节省神经学家和脑电图技术人员。 该软件将沿着当前的Persyst产品（Insight、SpikeDetector和Prism）一起销售，这些产品支持几乎所有主要的DEEG制造商并由其销售。

The proposed work offers enhancements to the MagicMarker software developed in Phase I. This software offers a new methodology for the display and analysis of long-term EEG records. Epochs of similar activity are grouped into segments and then states via two-pass hierarchial clustering. This results in clearly differentiated background, paroxysmal activity and patient state transitions. The underlying EEG is always available via hyper- links so that artifacts can be distinguished from "real EEG." The Phase II work adds classification abilities (intelligence) to the Phase I software. Proposed are an expert-level seizure detector, an ICU abnormality detector and a user-defined activity detector. The effort includes the development of a large library of carefully analyzed and annotated prolonged EEG studies. Newborns, older children and adults will be included ensuring robust algorithms for all age groups. The proposed software greatly reduces staff requirements for long-term monitoring through intelligent notification (visual, audible and dial-up pager) of interesting events. This, in addition to the ability to monitor patients "away from the lab," provides more frequent patient checks and improved clinical outcomes. PROPOSED COMMERCIAL APPLICATION The proposed software would be a valuable addition to any digital EEG because of the great timesavings it provides for both neurologists and EEG technicians. The software will be marketed along with current Persyst products (Insight, SpikeDetector and Prism), which support and are sold by virtually every major DEEG manufacturer.