DYNAMIC CARDIAC SPECT IMAGING

动态心脏单光子发射计算技术的发展 断层扫描(SPECT)有可能提供一种敏感的测量方法 并用多功能性来表征存活心肌 用全景成像的多功能性对全景进行成像 现有心脏放射药物的资料库。动态 心脏SPECT有可能获得更多，也许 比静态检查更好的诊断信息，无需额外费用 除了计算处理之外。 假设放射性示踪剂的药代动力学估计为 比视觉解读更敏感的心脏病测量方法 静态图像。拟议的工作将开发加工方法 犬99m/Tc-teboroxime和201/Tl心肌SPECT动态显像结果 模特和病人。单层和多层螺旋CT心脏SPECT动态显像 探测器SPECT系统将用于新算法的开发 重建生理运动模型参数的3D图像 没有来自动态获取的断层扫描的伪影的心脏 项目。将实现以下目标：(1)开发迭代 动态SPECT重建的直接矩阵求逆算法 数据。(2)动力学模型估计算法的发展 直接从投影测量中获取参数。(3)发展 感兴趣区域的自动分割和时间生成 血液、心肌和背景组织的活动曲线。(4)一个 SPECT物理和人体生理因素对偏差的影响分析 以及估计的动力学参数的方差。(5)发展一种 用估计值灵敏地测量缺血和存活心肌 99m/Tc-替波罗酮和201/Tl的动力学参数 拟议的工作将开发应用数学工具，以准确地 并精确量化动力学参数并系统地评估 这些方法通过计算机模拟、犬类实验和 临床研究。这项提案的目标是开发出 使用现有的单探测器和多探测器SPECT系统； 使动态SPECT即使在那些只有单一- 探测器SPECT系统，因此不能快速执行 收购。开发的技术将提供更好的医疗保健 通过更好地检测心肌梗死，更好地诊断 缺血性心脏病和更好的组织活性评估 不需要额外的SPECT程序费用。许多方法 开发的产品还将适用于含葡萄糖的心肌成像 类似物如18FDG和脂肪酸如123IPPA。它是 预计这些技术将适用于成像其他 器官系统，如肾脏和大脑。

The development of dynamic cardiac single photon emission computed tomography (SPECT) has the potential to offer a sensitive measure of ischemia and to characterize viable myocardium with a versatility of imaging the full armamentarium with versatility of imaging the full armamentarium of available cardiac radio-pharmaceuticals. Dynamic cardiac SPECT holds forth the potential of acquiring more and perhaps better diagnostic information than static studies at no additional cost aside from computational processing. The hypothesis is that estimates of pharmacokinetics of radiotracers are more sensitive measures of cardiac disease than visual interpretations of static images. The proposed work will develop methods of processing dynamic cardiac SPECT data of 99m/Tc-teboroxime and 201/Tl in canine models and patients. Dynamic cardiac SPECT using single- and multi- detector SPECT systems will be used in development of new algorithms that reconstruct 3D images of the physiological kinetic model parameters of the heart without artifacts from dynamically acquired tomographic projects. The following will be achieved: (1) Development of iterative and direct matrix inverse algorithms for reconstructing dynamic SPECT data. (2) Development of algorithms for estimating kinetic model parameters directly from projection measurements. (3) Development of automatic segmentation of regions of interest and generation of time activity curves for blood, myocardial, and background tissue. (4) An analysis of effects of SPECT physics and human physiology on the bias and variance of estimated kinetic parameters. (5) Development of a sensitive measure of ischemic and viable myocardium using estimated kinetic parameters of 99m/Tc-teboroxime and 201/Tl. The proposed work will develop applied mathematical tools to accurately and precisely quantify kinetic parameters and systematically evaluate these methods with computer simulations, canine experiments, and clinical studies. The goal of this proposal is to develop methods that use existing single- and multi-detector SPECT systems; and, in so doing, make dynamic SPECT useful even in those clinics which have only single- detector SPECT systems and are thus not able to perform rapid acquisitions. The developed techniques will provide improved health care through better detectability of myocardial infarcts, better diagnosis of ischemic heart disease, and better evaluation of tissue viability without additional cost for the SPECT procedure. Many of the methods developed will also be applicable to imaging the myocardium with glucose analogues such as 18FDG and fatty acids such as 123IPPA. It is anticipated that these techniques will be applicable to imaging other organ systems such as the kidney and the brain.