The Cambridge Initiative: Proposal to enhance linked research in human fat metabolism and pathophysiology between MRC HNR, MRC MDU and MRC Epi

肥胖是2型糖尿病的病因之一。然而，有些肥胖的人不会患上2型糖尿病，而另一些人似乎特别容易患上这种疾病。本项目旨在研究人体脂肪代谢以了解这一点。质谱法是一种分析技术，用于通过重量来识别不同的化学物质。我们还可以使用某些元素的天然非放射性重核（称为“稳定同位素”）来标记化学物质，并检测这些标记在体内的位置。这些技术正在帮助我们发展个性化营养和药物的概念-为个人量身定制饮食和治疗，以最大限度地发挥其作用。该项目的目的是研究脂肪是如何从体内吸收，在肝脏中加工，代谢和储存的。人们将被喂食含有标记脂肪的食物，看看标签在哪里，脂肪对新陈代谢有什么影响。我们还将研究不同的食物如何影响一顿饭中所摄入的脂肪的命运-例如，来自牛奶的脂肪是否与来自肉类的脂肪不同。通过了解健康人和糖尿病患者的脂肪代谢是如何控制的，我们将更好地了解2型糖尿病的原因，并找到预防和治疗这种疾病的新方法。

Obesity is one of the causes of type 2 diabetes. However, some people with obesity do not develop type 2 diabetes, while others seem particularly vulnerable to the disease. This project sets out to examine human fat metabolism to understand this.Mass spectrometry is an analytical technique used to identify different chemicals by how much they weigh. We can also use naturally occurring, non-radioactive heavy nuclei of certain elements (called 'stable isotopes') to label chemicals, and detect where these labels end up in the body. These techniques are helping us develop the concept of personalised nutrition and medicine - the tailoring of diets and treatments to an individual to maximise their effects. The aim of this project is to investigate how fats are absorbed by the body from the body, processed in the liver, metabolised and stored. People will be fed meals containing labelled fats to see where the label goes and what effects the fat has on metabolism. We will also study how different foods affect the fate of the fat eaten in a meal - for example whether fats from milk are treated differently to those from meat. By understanding how fat metabolism is controlled in healthy and diabetic people we will understand better the causes of type 2 diabetes and identify new ways to prevent and treat the disease.