The developmental role of metabolism, appetite and growth in eating disorders: exploring novel longitudinal risk pathways

进食障碍(完全和部分症状、厌食症、神经性暴食症和暴食症)是威胁生命的疾病，始于青春期，影响十分之一的青少年和年轻人。我们对饮食失调的原因缺乏了解，这影响了我们开发良好的治疗方法和充分预防饮食失调的能力。这个项目以我们的初步数据为基础，表明新陈代谢和生长可能在进食障碍的发展中发挥作用；旨在了解代谢功能、食欲和生长因素是否在进食障碍发生之前。我们还致力于探索这些因素是否可能与个人的基因构成有关，使用新的方法，并基于新的基因发现。这项研究将基于雅芳父母和孩子研究(ALSPAC)的数据，以及英国著名和独特的纵向研究。这项研究将为我们提供对青少年和年轻人饮食失调的新风险机制的了解，这些机制可以在本项目之后的更大和更详细的研究中进一步研究。

The Eating Disorders (full and partial syndrome anorexia nervosa and bulimia nervosa and binge eating disorder) are life-threatening illnesses that start in adolescence and affect between one and two in ten adolescents and young adults. There is a lack in our understanding of why eating disorders develop, which affects our ability to develop good treatments and adequately prevent eating disorders. This project builds on our preliminary data showing that metabolism and growth might play a role in the development of eating disorders; and aims to understand if metabolic function, appetite and growth factors precede onset of eating disorders. We also aim to explore whether these factors might be related to individuals' genetic make up, using novel methodologies and based on novel genetic findings. This study will be based on data from the Avon Study of Parents and Children (ALSPAC), and well-known and unique longitudinal study based in the UK. This study will be fundamental in providing us with an understanding of novel risk mechanisms for adolescent and young adult eating disorders that can be further investigated in larger and more detailed studies following this project.