CEREBRAL STRUCTURAL AND METABOLIC CORRELATES OF AGGRESSIVE OR ADDICTIVE BEHAVIOR

这项研究旨在确定人类受试者的成瘾和攻击/冲动行为的神经解剖学和神经化学相关性。这些研究的主要重点是使用正电子发射断层扫描(PET)测量和关联局部脑葡萄糖代谢活动、使用磁共振成像(MRI)测量脑体积、脑脊液代谢物以及冲动/攻击行为和过量饮酒的测量。我们使用1.5T扫描仪收集了完整的T-1加权磁共振图像，测量了68名酗酒者(38名男性和30名女性)和38名健康的非酒精对照受试者(19名男性和19名女性)的颅内体积。使用自动分割程序将脑内内容物分为脑脊液、灰质和白质(人脑图谱，5：194-205,1997)。我们还测量了穹隆的横截面积。由于女性的颅内体积明显小于男性，因此对性别进行了单独分析。与健康的非酗酒女性相比，女性酗酒者的大脑灰质和白质体积显著减少，脑室和脑沟脑脊液显著增加。酒精中毒者和非酒精者之间的灰质体积和穹隆体区面积均无显著差异。然而，酗酒的男性确实比不酗酒的男性有更多的脑脊液。女性似乎比男性更容易受到酒精中毒引起的脑损伤。与酗酒者的脑体积与对照组相比显着减少相反，我们发现两组的小脑体积没有显着差异。-神经科学、成像、正电子发射计算机断层扫描、核磁共振成像-人类受试者

This research is designed to determine neuroanatomical and neurochemical correlates of addictive and aggressive/impulsive behavior in human subjects. The principal focus of these studies is the measurement and correlation of regional cerebral glucose metabolic activity, using positron emission tomography (PET), brain volumes using magnetic resonance imaging (MRI), cerebrospinal fluid metabolites, and measures of impulsive/aggressive behavior and excessive alcohol consumption. We collected full, volumetric T-1 weighted MR images using a 1.5 T scanner to measure intra-cranial volumes in 68 alcoholics (38 males and 30 females) and 38 healthy, non-alcoholic comparison subjects (19 males and 19 females). An automated segmentation program was used to divide the intra-cranial contents into CSF, gray and white matter (Human Brain Mapping, 5:194-205, 1997). We also measured the cross sectional area of the corpus callosum. Since women have significantly smaller intra-cranial volumes than men, the genders were analyzed separately. Women alcoholics showed significant reductions in cerebral gray and white matter volumes compared to healthy non-alcoholic women, as well as significant increases in ventricular and sulcal CSF. Neither gray matter volume nor corpus callosum area differed significantly between alcoholic and non-alcoholic men. However, alcoholic men did have significantly more sulcal CSF than non-alcoholic men. Women appear to be more susceptible to alcoholism associated brain damage than men. In contrast to the significant reductions in cerebral volume of alcoholics compared to controls we have found no significant difference in the cerebellar volume of the two groups. - neurosciences, imaging, PET, MRI - Human Subjects