HARVARD MENTORED CLINICAL SCIENTIST DEVELOPMENT PROGRAM

这项修订后的竞争性续签提案寻求支持，以继续颁发由NIA资助的高度成功的临床科学家指导发展计划奖。该计划代表着医学院、公共卫生学院以及朗伍德医疗区和波士顿周围的附属机构之间的重大、多学科和跨部门的合作。我们加大了广泛招募候选人的力度，包括那些在老龄化研究中属于代表性不足的少数族裔的人，以及来自其他医学院的人，包括骨科学校。我们已经提供了八名优秀的潜在实习生候选人的信息，其中五名是女性，三名是非裔美国人，一名是西班牙裔，一名是一名骨科医生，在缅因州农村与服务不足的老年人(包括美洲原住民)一起工作。这些候选人中有许多人对公共和社会医学方面的研究感兴趣，特别是在美国服务不足、市中心和服务不足的农村社区的少数族裔老年人的护理方面。拟议的计划旨在支持和加强几个相互关联的老年学学科的研究经验。将强调六个具体领域。这些疾病包括(1)心血管疾病、(2)细胞增殖障碍、(3)神经退行性疾病和痴呆症、(4)内分泌/肾功能障碍、(5)老年综合征和(6)公共卫生。50多名经验丰富、资金充足的学院科学家(其中20名是女性)，其中许多是老牌老年学研究人员，将作为临床科学家实习生的潜在初级或次级导师。实施了双重指导制度，以确保不断接触老年学/老年医学的专门知识和情况介绍。最终，我们计划将受训人员培养成临床医生调查人员，他们可以促进将重要的研究成果转化为改善对所有老年美国人的护理。

This revised competing renewal proposal seeks support to continue a highly successful, NIA-funded Mentored Clinical Scientist Development Program Award. The program represents a major, multidisciplinary and interdepartmental collaboration among the medical school, school of public health, as well as the affiliated institutions in the Longwood Medical Area and around Boston. We have increased our efforts at recruiting candidates widely, including those who are members of under-represented minorities in aging research, and those who are from other medical schools including schools of osteopathy. We have provided information on eight superb prospective trainee candidates of which five are women, three are African American, one is Hispanic, and one is a doctor of osteopathy working with underserved elderly (including Native Americans) in rural Maine. Many of these candidates are interested in pursuing research in public and social medicine, especially the care of minority elderly in the underserved, inner-city and underserved rural communities of America. The proposed Program is designed to support and enhance research experience in several interrelated gerontologic disciplines. Six specific areas will be emphasized. These are (1) cardiovascular disease, (2) cell proliferation disorders, (3) neurodegenerative disease and dementia, (4) endocrine/renal dysfunction, (5) geriatric syndromes, and (6) public health. More than 50 experienced, well-funded faculty scientists (20 of whom are women), many of whom are established gerontologic investigators, will serve as potential primary or secondary mentors for the clinician scientist trainees. A dual mentoring system has been implemented to ensure ongoing exposure to gerontologic/geriatric expertise and orientation. Ultimately, we plan to develop the trainees into clinician investigators who can facilitate the translation of important research findings into improved care for all older Americans.