CARDIOVASCULAR RESEARCH TRAINING

在这份修订后的提案中，我们提出了一项心血管培训计划，以培训医学博士和博士后研究员，以发展必要的基本科学研究人员技能，以调查心血管疾病发展的病理生理学和机制。一种统一的研究方法是由一个高度互动的基础科学研究人员小组尽可能地将基础基础科学的信息与临床领域相结合，这些研究人员专注于四个核心领域，包括：1)膜蛋白生物化学，2)血管生物学，3)发育生物学和(4)心脏电生理学。该计划最初是在1977年资助的，后来进行了修订，以创造一个培训环境，让医学博士和博士在同一个基础实验室接受博士后培训，以促进基础科学家和临床医生之间的互动，并弥合基础知识和临床应用之间的鸿沟。在这笔赠款的支持下，我们打算为四类研究员提供基础科学培训：1)希望在基础实验室呆至少两年的医学博士；2)作为ABIM新研究途径(以前的临床研究途径)的一部分，在基础实验室呆三年；3)在研究项目中呆五年以获得博士学位；以及4)希望在基础实验室呆至少三年的博士后博士。参加的基础科学系包括：1)生理学和生物物理学；2)生物化学和分子生物学。威尔斯儿科研究中心和电气工程部也参与了这项研究。这一高度互动和多学科的项目将内科研究人员和基础科学家聚集在一起，他们在了解心血管过程的生理学和病理生理学方面有着共同的兴趣。此外，该计划非常适合于有效地招募代表不足的少数族裔。作为这项资助的一部分，我们建议每年培训3名博士后研究员，为期2年。

In this revised proposal, we present a cardiovascular training program to training program to train M.D. and Ph.D. postdoctoral Fellows to develop the necessary basic science investigator skills to investigate the pathophysiology and mechanisms underlying the development of cardiovascular disease. A unifying research approach is to integrate information from the basic bench science with clinical areas as much as possible by a highly interactive group of basic science investigators focused on four core areas including: 1) membrane protein biochemistry, 2) vascular biology, 3) developmental biology and (4) cardiac electrophysiology. The program was funded initially in 1977 and has been revised to create a training environment in which both M.D.s and Ph.D.s receive postdoctoral training in the same basic laboratories to foster interactions between basic scientists and clinicians, and bridge the chasm between fundamental knowledge and clinical application. Under support from this grant, it is our intent to offer basic science training to four categories of Fellows: M.D.s who wish to spend at least 1) two years in a basic lab; 2) three years in a basic lab as part of the ABIM's new research pathways (formerly the Clinical Investigator Pathway); 3) five years in a research program to obtain a Ph.D.; and 4) postdoctoral Ph.D.s who wish to spend at least three years in a basic lab. Participating basic science departments include: 1) Physiology and Biophysics, 2) Biochemistry and Molecular Biology. Also participating is the Wells Center for Pediatric Research and the Department of Electrical Engineering. This highly interactive and multi-disciplinary program brings together physician investigators and basic scientists and basic scientists who share common interests in understanding the physiology and pathophysiology of cardiovascular processes. In addition, the program is ideally suited to effectively recruit under-represented minorities. We proposed to train 3 postdoctoral Fellows each year for 2 years as part of this grant.