Identification of Metabolic Phenotypes and Systemic Biochemical Reaction Networks Associated with Human Blood Pressure

高血压是代谢综合征的一个重要组成部分，也是人类心血管疾病和非传染性疾病最常见的可改变风险因素之一。高血压仍然是全球疾病负担的主要原因，据估计，全球有1070万人死于高血压。已经采用了不同的临床和全民策略来降低高血压，例如减缓肥胖的增加、增加体育活动、减少烟草使用和改变饮食模式，包括减少盐的摄入量。然而，需要更好地了解高血压对人体代谢的影响，以便深入了解控制血压的分子机制。人类代谢表型反映了个体的健康状况，并受到遗传、环境、饮食和肠道微生物变异的影响。我建议使用代谢表型方法来发现尿液中与血压和相关饮食模式相关的生化化合物（代谢物），并研究这些潜在的临床代谢靶点如何适应与高血压发病和血压稳态调节相关的生化过程。

High blood pressure is an important component of metabolic syndrome and one of the most common modifiable risk factors for human cardiovascular disease and non-communicable disease. High blood pressure remains to be the leading cause for global disease burden and is estimated to attribute to 10.7 million deaths globally.Different clinical and population-wide strategies have been in use to reduce high blood pressure such as to slow the rise of obesity, to increase physical activity, to reduce tobacco use and to change dietary patterns including the reduction of salt intake.However, better knowledge of the effects of high blood pressure on human metabolism is needed to provide insight into the molecular mechanisms by which blood pressure is controlled. The human metabolic phenotype reflects the health status of an individual and is affected by genetic, environmental, dietary and gut-microbial variation.I propose to use a metabolic phenotyping approach to discover biochemical compounds (metabolites) in urine related to blood pressure and associated dietary patterns, and to investigate how these potential clinical metabolic targets fit in the biochemical processes involved with the onset of high blood pressure and homeostatic regulation of blood pressure.