METABOLISM IN GAMMA-GLUTAMY1 TRANSPEPTIDASE DEFICT MICE

描述：首席研究人员最近培育出的小鼠 缺乏谷氨酰转肽酶(以下简称GGT)，a 谷氨酰胺循环和谷胱甘肽代谢中的关键酶。他 现在的目标是将这些GGT缺陷小鼠用于四个目的：1) 确定为什么缺陷小鼠在生长和性成熟方面落后；2)如果 缺陷小鼠包含其他GGT样活性；3)更充分 说明GGT在谷胱甘肽和氨基酸代谢中的作用； 以及4)检测GGT代谢途径在诱导的两个 疾病状态，氨基半乳糖/内毒素引起的肝损伤和 甲基汞的代谢和毒性。

DESCRIPTION: The principal investigator has recently generated mice that lack g-glutamyl transpeptidase (hereafter referred to as GGT), a critical enzyme in the g-glutamy cycle and glutathione metabolism. He now aims to use these GGT- deficient mice for four purposes: 1) to determine why deficient mice lag in growth and sexual maturation; 2) if deficient mice contain other GGT-like activities; 3) to more fully characterize the role of GGT in glutathione and amino acid metabolism; and 4) to examine the role of GGT metabolic pathways in two induced disease states, galactosamine/endotoxin induced liver injury and methylmercury metabolism and toxicity.