Characterisation of oligodendrocyte plasticity in the adult median eminence and its role in the regulation of energy balance

少突胶质细胞是一种脑细胞，它将轴突隔离以允许电信号的快速传输。它们是在人类生命的最初几年形成的，但最近的研究表明，一些在成年后继续形成，以应对环境挑战，例如在获得新的运动技能的过程中。我们发现，营养信号调节成年人大脑中控制食欲和体重增加的区域中新少突胶质细胞的形成。我们的目标是确定这些新细胞如何有助于调节食欲和维持体重，以及这一过程是否在肥胖中受损。这项研究将增加我们对营养如何调节1-成年人新少突胶质细胞的形成，以及2-控制食欲和体重的大脑通路的理解。潜在的应用包括治疗肥胖和脱髓鞘疾病（如多发性硬化症）的新治疗策略。

Oligodendrocytes are brain cells that isolate axons to allow fast transmission of electrical signals. They are formed during the first years of life in humans, but recent studies show that some continue to be formed in adulthood in response to environmental challenges, for example during the acquisition of new motor skills. We found that nutritional signals regulate the formation of new oligodendrocytes in adults in a region of the brain that controls appetite and weight gain. Our aim is to determine how these new cells contribute to the regulation of appetite and the maintenance of body weight, and whether this process is impaired in obesity. This research will increase our understanding of how nutrition regulates 1-the formation of new oligodendrocytes in adults, and 2- brain pathways controlling appetite and body weight. Potential applications include new therapeutic strategies for the treatment of obesity and demyelinating diseases like multiple sclerosis.