A prospective multicenter birth cohort study of iron adaptive homeostasis, growth and development in three Peruvian regions

秘鲁是一个南美洲国家，在过去的二十年里，经济持续增长，人口财富增加。然而，在秘鲁，仍有很大比例的儿童由于血液中铁含量不足而患贫血症。这种情况对秘鲁儿童的未来及其成年人的健康造成了极大的危害。这一问题的根源可能很复杂，因为许多生态、生物、社会和政治因素在一定程度上解释了贫血持续存在的原因。目前，政府的大多数干预措施侧重于治疗，而不是预防。然而，治疗这种疾病可能会有副作用，因为过多的铁，与其他营养或环境因素相互作用，也会对生长和发育产生负面影响。在这个项目中，我们将研究环境和营养因素的复杂性，这些因素改变了一组秘鲁婴儿从出生到一岁的铁平衡机制。儿童和他们的母亲将在位于秘鲁沿海、安第斯山脉和亚马逊的3个城市接受研究。将对水、血液、粪便进行各种测量和采样;将收集婴儿尺寸测量、访谈、营养观察和参与母亲的焦点小组。还将对过去实施的一些卫生政策和战略进行评价。

Peru is a South American country which in the last two decades has experienced a continuous economic growth and has improved its population wealth. However, in Peru still a large proportion of children are suffering from anaemia due to insufficient iron levels in their blood. That situation generates a great hazard to the future of Peruvian children and their adult health. The roots of this problem are likely to be complex because numerous ecological, biological, social and political factors explain in part the persistence of anaemia. The majority of the government interventions are currently focussed on treatment and not to prevention. However, treating this disease might have side effects, as too much iron, interacting with other nutritional or environmental factors, can also negatively affect growth and development.In this project, we will study the complexity of environmental and nutritional factors that alter the mechanisms of iron balance in a group of Peruvian babies, from birth to their first year of life. Children and their mothers will be studied in 3 cities in Peru located on the coast, the Andes and the Amazon. Various measurements and samples of water, blood, faeces will be made; baby size measurement, interviews, nutritional observation and focus groups with participating mothers will be collected. Some health policies and strategies implemented in the past will also be evaluated.