CORE CENTER FOR SKELETAL INTEGRITY

成立骨骼完整性核心中心的建议是在 特别外科医院(HSS)研究部。这个 该中心将得到NIH赞助的HSS Working的调查人员的支持 在骨骼发育和修复领域，研究人员为谁 骨骼完整性(生物、化学和机械影响 使骨骼成为如此独特的组织)是 研究。所有研究问题的关键是 组成、结构和功能，使骨骼能够完成 它的独特作用。这三个重要因素控制着骨骼 诚信及其衡量和评估对所有人都很重要 学科，从分子生物学到生物力学，以及所有级别的 从分子到整个器官。《核心》 因此，中心的目的是为调查人员提供工具 建立化学成分、超微结构 形态、组织和整个骨骼的力学性能 在他们的研究工作中使用这些工具的培训。同样 重要的是，该中心内的技术和科学专业知识 将作为多学科研究的焦点，因此 激励研究人员将他们的研究扩展到自己的研究之外 菲尔德。该中心将由三个研究中心组成，分析 显微镜、红外成像和机械测试，由 管理核心。该中心将为调查人员提供 共享技术(以及必要的设备和设施，以 利用它们)，并通过培训和技术支持来执行这些 技巧。该中心还将初步支持两名飞行员和 从年轻的研究人员那里获得可行性资助，并为他们提供 技术支持和导师为他们的研究事业提供帮助 发展。最后，该中心将开展一项浓缩项目 旨在鼓励核心用户之间的互动和协作 并在调查人员在 研究核心。

The formation of a Core Center for Skeletal Integrity is proposed within the Research Division of the Hospital for Special Surgery (HSS). The Center will be supported by NIH-sponsored investigators at HSS working in the area of bone development and repair, investigators for whom skeletal integrity (the biological, chemical and mechanical influences that make bone such a unique tissue) is a fundamental part of the research. Key to all the research questions is the relation between composition, structure, and function that allows the skeleton to fulfill its unique role. These three important factors control skeletal integrity and their measurement and evaluation are important across all disciplines, from molecular biology to biomechanics, and at all levels of tissue organization, from molecules to the whole organ. The Core Center is intended, therefore, to provide investigators with tools for establishing chemical composition, ultra- and microstructural morphology, and tissue and whole bone mechanical properties and with training to use these tools in their research efforts. Equally important, the techniques and scientific expertise within the Center will serve as a focal point for multi-disciplinary research, thus inspiring researchers to expand their investigations beyond their own field. The Center will consist of three research cores, Analytical Microscopy, Infrared Imaging, and Mechanical Testing, organized under an Administrative Core. The Center will provide investigators with access to shared techniques (and the necessary equipment and facilities to utilize them) and with training and technical support to perform these techniques. The Center will also initially support two Pilot and Feasibility grants from young investigators and provide them with technical support and with mentors to help in their research career development. Finally, the Center will conduct an enrichment program aimed at encouraging interaction and collaboration between core users and at informing investigators as they become available within the research cores.