CORE--MECHANICAL TESTING

核心--机械测试

• 批准号: 6315643
• 负责人: TIMOTHY M. WRIGHT
• 金额: $ 10.7万
• 依托单位: HOSPITAL FOR SPECIAL SURGERY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6315643
• 关键词: animal tissue; biomechanics; biomedical facility; bone; mechanical stress

The mechanical testing effort at the Hospital for Special Surgery needs to adapt its focus, reach out and expand collaborative relations, and respond to the needs of a new user base. HSS investigators have pioneered bone mechanical testing and performed many fundamental characterizing bone material properties from a purely mechanical perspective. Advances in molecular biology and genetics now allow identification of local and systemic factors that can affect skeletal integrity, so that the emphasis can become more integrated between "biological" and "engineering" experiments. Therefore, the goal of the Mechanical Testing Core is to organize and enhance the testing facility at HSS by providing testing equipment and methodologies for material and structural characterization of bone, by training investigators in the use and interpretation of material and structural testing, and by developing new applications and methodologies to fit the research programs of investigators within the Core Center's biomedical research base. New testing approaches suitable to the biological approaches being used in current and planned experiments described elsewhere in the Core Center proposals are being developed, particularly for in vivo small animal experiments. These efforts were begun as part of a "small animal testing" user groups, consisting of bioengineers, clinicians, biologists, chemists, and their students, that has been active for the past year (and which was the initiation point for the Core Center proposal). The changes required to organize and refocus the mechanical testing effort can be made within the existing infrastructure, using well-established techniques developed at HSS.

特殊外科医院的机械测试工作需要 调整其重点，扩大合作关系，并 满足新用户群的需求。HSS调查人员 开创了骨力学测试的先河， 从纯粹的机械特性 perspective.分子生物学和遗传学的进步现在允许 识别可能影响骨骼的局部和全身因素 完整性，以便重点可以变得更加一体化， “生物”和“工程”实验。因此， 机械试验的核心是组织和加强试验设施 在HSS提供材料测试设备和方法， 骨的结构表征，通过培训研究人员在 材料和结构测试的使用和解释，以及 开发新的应用程序和方法，以适应研究 核心中心生物医学研究中的研究人员计划 基地适用于生物学方法的新测试方法 用于核心文件其他部分描述的当前和计划的实验 正在制定中心提案，特别是体内小 动物实验。这些努力开始作为一个“小动物”的一部分， 测试”用户组，由生物工程师，临床医生， 生物学家，化学家和他们的学生，一直活跃在 去年（也是核心中心的启动点 建议）。组织和重新聚焦机械所需的更改 测试工作可以在现有的基础设施内进行，使用 HSS开发的成熟技术。