MICRO-COMPUTED TOMOGRAPHY SYSTEM

显微计算机断层扫描系统

• 批准号: 6053115
• 负责人: TIMOTHY M. WRIGHT
• 金额: $ 17.8万
• 依托单位: HOSPITAL FOR SPECIAL SURGERY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6053115
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; computed axial tomography; personal computers

We would like to purchase a microcomputed tomography (micro-CT) system for the Hospital for Special Surgery to acquire high resolution morphometry and density information from bone samples. Several NIH- sponsored investigators at our institution and at other academic institutions in New York City are studying bone development, repair, and adaptation. For these investigators, understanding skeletal integrity (the biological, chemical, and mechanical influences that make bone such a distinctive tissue) is a fundamental part of their research. Taking advantage of advances in molecular biology and genetics, these researchers are integrating biology and engineering into in vivo experiments using small anhnal models to examine the relation between composition, structure, and function that allows the skeleton to fulfill its unique role. The purchase of a micro-CT system will provide crucial detailed structural information on the small bones from these animals that will complement compositional measurements (from infrared imaging) and functional data (from mechanical testing and finite element analyses). For example, the ability to resolve morphomet:ric details at nearly the same resolution (<20 microns) with micro-CT as we are able to resolve mineral and matrix compositional properties (< 10 microns) with infrared imaging creates unique capabilities to examine composition-structure-function relations in trabecular bone at ultrastructural levels of tissue organization. The value of micro-CT has been demonstrated in preliminary studies in which time has been borrowed on a system in The Netherlands. However, the large number of investigators who could benefit and the large number of new research questions that will arise by having a system at our institution far outweighs our ability to acquire sufficient time on other systems. The grant for the micro-CT system will be administered within the Core Center for Skeletal Integrity, a new NIH-sponsored center (p30 AR46121) organized under an Administrative Core with research cores in Analytical Microscopy, Infrared Imaging, and Mechanical Testing. The micro-CT system will be housed within the Analytical Microscopy core, and policies and procedures for its use, maintenance, and oversight will follow from those already established for the Core Center. This administrative procedure will insure optimal use, long-term operation, and maintenance of the equipment as part of the institution's commitment to the Core Center.

我们想为特殊外科医院购买一台微型计算机断层扫描(Micro-CT)系统，以便从骨骼样本中获得高分辨率的形态测量和密度信息。我们机构和纽约市其他学术机构的几名NIH赞助的研究人员正在研究骨骼的发育、修复和适应。对于这些研究人员来说，了解骨骼的完整性(使骨骼成为如此独特的组织的生物、化学和机械影响)是他们研究的基础部分。利用分子生物学和遗传学的进步，这些研究人员正在将生物学和工程学整合到活体实验中，使用小肛门模型来检查使骨骼发挥其独特作用的成分、结构和功能之间的关系。购买微型CT系统将提供这些动物小骨的关键详细结构信息，这些信息将补充成分测量(来自红外成像)和功能数据(来自机械测试和有限元分析)。例如，使用Micro-CT以几乎相同的分辨率(&lt；20微米)解析形态：RIC细节的能力，就像我们能够用红外成像解析矿物和基质的组成属性(&lt；10微米)一样，创造了在组织组织的超微结构水平上检查松质骨中的成分-结构-功能关系的独特能力。微型CT的价值已经在荷兰的一个系统上借用时间进行的初步研究中得到了证明。然而，在我们机构建立一个系统可以受益的大量调查人员以及将出现的大量新的研究问题，远远超过了我们在其他系统上获得足够时间的能力。微型CT系统的拨款将在骨骼完整性核心中心内管理，这是一个由NIH赞助的新中心(P30 AR46121)，由一个行政核心组织，研究核心是分析显微镜、红外成像和机械测试。微型CT系统将安装在分析显微镜核心内，其使用、维护和监督的政策和程序将遵循已经为核心中心制定的政策和程序。该管理程序将确保设备的最佳使用、长期运行和维护，作为机构对核心中心的承诺的一部分。