CONFERENCE--JOINT IMPLANT WEAR PROBLEMS 2000

会议——2000 年关节植入物磨损问题

• 批准号: 6164035
• 负责人: TIMOTHY M. WRIGHT
• 金额: $ 2.25万
• 依托单位: AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-15 至 2001-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6164035
• 关键词: biomaterial compatibility; biomaterial development /preparation; biomaterials; biomechanics; joint prosthesis; mechanical stress; medical implant science; meeting /conference /symposium; technology /technique development; tissue engineering; travel

Total joint arthroplasty is an effective treatment for relieving pain and restoring function for patients with diseased or damaged joints. Hundreds of thousands of total joint replacements are implanted each year in the United States alone, and these numbers will increase as the population continues to age and as the indications for joint arthroplasty extend to younger patients. Despite this clinical success, many patients require painful and costly revision surgery because their joint replacements loosen secondary to implant wear and the associated osteolysis. Wear of the surfaces of the man-made materials that form the joint implant is now recognized as the major obstacle to long-term success and has been the focus of considerable research aimed at understanding the clinical, biological, engineering and materials factors that influence the wear process. Research questions based on these factors formed the agenda of a 1995 NIH/AAOS workshop attended by clinicians, biologists, engineers, and materials scientists studying the wear problem. In the ensuing few years, clinical concern has grown, but fortunately has been accompanied by important advances in understanding the clinical impact of the problem, the biological reaction to wear debris, and design and material factors that control mechanics of wear. Given these discoveries, a follow-up workshop is proposed with the goals of: defining the current research knowledge base on the wear problem; addressing intervention and prevention strategies involving biological, biomechanical, and biomaterials solutions; attracting new investigators to research the wear issue; and drafting a proceedings for rapid and widespread dissemination of workshop findings on the internet. The emphasis will be on reviewing what is known about implant wear, defining what important aspects remain unknown, and identifying future research directions.

全关节置换术是治疗关节病变或受损患者缓解疼痛、恢复功能的有效方法。仅在美国，每年就有数十万例关节置换术，随着人口的不断老龄化和关节置换术的适应症扩展到更年轻的患者，这个数字还会增加。尽管取得了临床上的成功，但许多患者需要痛苦和昂贵的翻修手术，因为他们的关节置换因种植体磨损和相关的骨溶解而继发松动。形成关节植入物的人造材料表面的磨损现在被认为是长期成功的主要障碍，并已成为旨在了解影响磨损过程的临床、生物、工程和材料因素的大量研究的重点。基于这些因素的研究问题形成了1995年NIH/AAOS研讨会的议程，临床医生、生物学家、工程师和材料科学家参加了会议，研究磨损问题。在接下来的几年里，临床关注有所增加，但幸运的是，在了解该问题的临床影响、磨损碎片的生物反应以及控制磨损机理的设计和材料因素方面取得了重要进展。鉴于这些发现，拟举办一次后续研讨会，其目标是：确定当前关于磨损问题的研究知识库；解决涉及生物、生物力学和生物材料解决方案的干预和预防战略；吸引新的研究人员研究磨损问题；起草一份会议记录，以便在互联网上迅速和广泛地传播研讨会的研究结果。重点将是回顾关于种植体磨损的已知情况，确定哪些重要方面仍然未知，并确定未来的研究方向。