CORE--GHC POPULATION AND SURVEILLANCE

该核心的总体目标是支持各个项目， 通过识别和招募患者， 参与计划项目研究，通过收集胃肠道 癌症组织来自大约 400，000名注册者，并通过提高计划项目的能力， 研究者在结肠和胰腺中进行纵向研究 癌通过健康研究中心，GHC人口核心 将促进获得具有独特的医疗保健服务系统， 作为翻译研究的设置，包括一个大的优势 明确的患者人群和丰富的信息系统; 建立与风险因素相关的癌症筛查计划， 病理结果;以及设计、实施和分析经验 对癌症预防、控制和治疗的干预和观察研究 和治疗。 GHC人口核心的具体目标是： 收集慢性胰腺炎患者的标本， 癌症和结肠癌的拟议项目1和4; 2）招募 接受结肠镜检查的患者，并收集风险因素数据、粪便和 血液样本、活检结果和组织标本， 结肠癌风险和发展的研究;以及4）建立一个 监察系统监察肠胃癌的转变 我们定义的人群中的发病率、发病率和死亡率。的GHC 人口核心将建立和维护一个回顾性登记研究， 超过9800名患者的相关病理结果， 1991年至1996年之间的结肠镜检查，并将增加风险因素的数据， 预计将有4800名患者在项目期间接受结肠镜检查 期 团体健康合作社（GHC）是一个员工模式的管理式医疗组织 为华盛顿普吉湾西部的40多万注册者提供服务 地区GHC人口核心将在GHC中心内运作， 健康研究，一个研究组织，致力于进行 有助于公共领域科学知识的研究， GHC的医疗质量

The Overall goal of this Core is to support individual projects and overall objectives by identifying and recruiting patients for participation in Program Project Studies, by collecting gastrointestinal cancer tissues from cases that arise in a population of approximately 400,000 enrollees, and by enhancing the ability of Program Project investigators to conduct longitudinal studies in colon and pancreas cancer. Through the Center for Health Studies, the GHC Population Core will facilitate access to a health care delivery system that has distinct advantages as a setting for translational research that include a large defined patient population and a rich array of information systems; established programs in cancer screening with linkage to risk factors and pathologic outcomes; and experience in the design, conduct, and analysis of intervention and observational studies of cancer prevention, control and treatment. The specific aims of the GHC Population Core are: 1) To identify and collect specimens from patients with chronic pancreatitis, pancreatic cancer, and colon cancer for proposed projects 1 and 4; 2) To recruit patients undergoing colonoscopy and collect risk factor data, fecal and blood samples, and biopsy results, and tissue specimens for longitudinal studies of colon cancer risk and development; and 4) To establish a surveillance system to monitor changes in gastrointestinal cancer incidence, morbidity, and mortality in our defined population. The GHC Population Core will build and maintain a retrospective registry with linked pathology results of more than 9800 patients who underwent colonoscopy between 1991 and 1996 and will add risk factor data for the anticipated 4800 patients who will be colonoscopied during the project period. Group Health Cooperative (GHC) is a staff-model managed care organization that serves over 400,000 enrollees in the western Washington Puget Sound region. The GHC Population Core will operate within the GHC Center for Health Studies, a research organization dedicated to the conduct of studies that contribute to scientific knowledge in the public domain and to the quality of health care at GHC.