A Novel High Intensity Short Interval Dance Intervention for Non Communicable Disease(NCD) Prevention in Asian Indian Adolescent Girls-THANDAV

一种用于预防亚洲印度青春期女孩非传染性疾病(NCD)的新型高强度短间隔舞蹈干预--THANDAV--一项初步研究。这项拟议的发展赠款议定书将在印度进行，期限为18个月。我们将测试一种个性化的锻炼和教育干预，并借助数字技术来提供这种新颖的THANDAV(为青少年提供HIIT和舞蹈以战胜非传染性疾病)干预。主要的研究问题将是--在10-17岁的亚裔印度女孩中，适合文化的高强度短时间(10分钟)舞蹈干预能否成为可持续的运动，以改善她们的身体健康并预防非传染性疾病？非传染性疾病造成的负担已经达到爆炸性的比例，增幅最大的是印度等低收入和中等收入国家。印度的运动水平低得惊人，女性的运动量比男性少。青少年参加体育活动的好处是有目共睹的，大多数全球指南建议每天至少进行60分钟的中等到剧烈的体育活动。有证据表明，青春期是体力活动下降最严重的时期，因此我们选择的队列是糖尿病和其他非传染性疾病的高危年龄段。印度2型糖尿病的发病年龄在25-34岁之间。因此，努力在青少年中推广体育活动是至关重要的。女性锻炼的障碍包括时间限制和锻炼在文化上不被接受。在印度，舞蹈是一种被社会和文化所接受的活动形式。我们假设，THANDAV干预的短期和趣味性因素，加上舞蹈在文化和社会上的可接受性，将有助于这种干预的长期可持续性，这对预防NCD至关重要。我们的目的是调查干预措施的发展、可行性和可接受性，并由此改善青少年的体力活动和健康水平。因此，主要结果将是增加以步数衡量的体力活动，从而改善以心率衡量的青春期女孩的健康水平。在通过这项试点研究评估了干预的方法和影响后，我们计划申请全额试验拨款，其中我们将以随机对照试验模式，通过简易数字设计评估THANDAV干预对有形代谢健康结果的可持续影响。全部试验拨款的结果将是代谢参数，包括体重、体脂、血压、血糖、血脂、胰岛素以及包括可持续性和可扩展性在内的重要结果指标。MDRF自2017年以来一直与来自苏格兰邓迪大学(UoD)的多学科调查人员合作，作为为期4年的NIHR全球糖尿病结果研究全球卫生研究单位的一部分。印度-苏格兰糖尿病精准医学伙伴关系(INSIGNAL)项目旨在提高对糖尿病及其并发症高负担背后的遗传、生活方式和环境因素的了解。THANDAV的提议是这种现有合作的延伸，科林·帕尔默博士是来自苏格兰邓迪大学(UoD)(英国)的联合调查员。

A Novel High Intensity Short Interval Dance Intervention for Non Communicable Disease (NCD) Prevention in Asian Indian Adolescent Girls - THANDAV - a pilot study. This proposed developmental grant protocol will take place in India with a duration of 18 months. We will test a personalized exercise and education intervention, aided by digital technology to deliver this novel 'THANDAV' (Taking HIIT And Dance to Adolescents for Victory over NCDs) intervention. The principal research question will be - Can a culturally appropriate high intensity short duration (10 min) dance intervention become sustainable exercise in Asian Indian girls aged 10- 17 years to improve their physical fitness and prevent NCDs? The burden due to NCDs has reached explosive proportions with the largest increases happening in low and middle-income countries like India. Exercises levels are abysmally low in India with women being less active than men. The benefits of physical activity in adolescents and youth are well established, with most global guidelines recommending at least 60 minutes of moderate to vigorous physical activity per day. Evidence suggests that adolescence is the time of steepest decline in physical activity, thus making our chosen cohort high-risk age group for diabetes and other non-communicable diseases. The age of onset of type 2 diabetes in India is in the age group of 25- 34 years. Hence, efforts to promote physical activity among adolescents and youth are essential.The barriers to exercising in females include time constraints and exercise not being 'culturally acceptable'. Dance is a socially and culturally accepted form of activity in India. We hypothesize that the short duration and fun element of the THANDAV intervention, coupled with the cultural and social acceptability of dance, will aid the long-term sustainability of such an intervention, which is vital for NCD prevention. We aim to investigate the development, feasibility, acceptability of the intervention and resulting improvements in physical activity and fitness levels in adolescents. The primary outcome will thus be increases in physical activity as measured by step count leading to improvement in fitness levels as measured by heart rate of adolescent girls. After assessing the methodology and impact of the intervention through this pilot study, we plan to apply for the full trial grant wherein we will evaluate the sustainable impact of the THANDAV intervention with an improvised digital design on tangible metabolic health outcomes in a randomized controlled trial mode. The outcomes in the full trial grant will be metabolic parameters including weight, body fat, blood pressure, glucose, lipids, insulin along with important outcome measures including sustainability and scalability. MDRF has been collaborating with multi-disciplinary investigators from the University of Dundee (UoD), Scotland (UK) since 2017 as part of a 4-year NIHR Global Heath Research Unit on Global Diabetes Outcomes Research. The India-Scotland Partnership for Precision Medicine in Diabetes (INSPIRED) project aims to improve the understanding of genetic, lifestyle and environmental factors underlying the high burden of diabetes and its complications. The THANDAV proposal is an extension of this existing collaboration with Dr. Colin Palmer being the Co-Investigator from University of Dundee (UoD), Scotland (UK).