Enhancing functional capacity in older adults with short session high intensity interval training

通过短期高强度间歇训练提高老年人的功能能力 虚弱是一种生理储备不足的状况，会增加对福尔斯的敏感性， 住院、残疾和死亡率。在65岁以后，虚弱的发生率迅速增加， 在85岁或以上的人中，从10%增加到50%;因此，超过900万退伍军人 要么虚弱要么有虚弱的危险运动已被证明对虚弱有益，但老年人很少能达到 建议每周进行150分钟的中等强度运动。高强度间歇训练（HIIT） 正在成为一种替代方案，因为它提供了类似或更好的收益比中等强度的运动， 时间最近，我们发表了一个每周3天，10分钟的HIIT方案在老年小鼠中不仅减少了 但同时带来力量和耐力的好处。此外，我们的初步数据表明， microRNA（miRNA）谱的显著变化。尽管短期会议HIIT的潜力， 提高功能能力， 坚持，该模式尚未测试 在65-85岁的个体中， 特别脆弱的人这个的目标 建议是：1）调查的可行性 招聘和管理短期会议 HIIT至虚弱、虚弱前期和非虚弱老年人 退伍军人和2）描述物理 性能优势和血清microRNA （miRNA）在这些参与者中的分布。 为了实现我们的目标，我们将管理一个短期HIIT方案，总共只有10- 分钟，每周3天，持续3个月，使用横卧运动周期，65-85岁的参与者。 我们还将利用下一代RNA测序技术来评估HIIT对microRNA的影响 血清样品中的特征。我们预计我们的项目将证明管理的可行性 对老年人进行短期HIIT，包括脆弱和虚弱前人群，以及 证明收集和分析血清miRNA谱的能力。该计划的优势 是维持或建立肌肉质量和改善有氧条件的能力，特别是在老年人中， HIIT增强身体表现，减少虚弱 在老化过程中。 虚弱和肌肉减少症非常普遍的病人。因此，这一试点项目将奠定基础， 未来的临床试验，进一步探索HIIT的效用，以防止或延迟发病的脆弱， 更大的队列，并最终导致我们的功能能力和生活质量的提高， 老龄化的退伍军人群体

Enhancing functional capacity in older adults with short session high intensity interval training Frailty is a condition of poor physiological reserve that increases susceptibility to falls, hospitalization, disability and mortality. The incidence of frailty rapidly increases after the age 65, growing from 10% to as many as 50% of those 85 years or older; therefore over 9 million veterans are either frail or at risk for frailty. Exercise has proven benefits for frailty, yet older adults rarely attain the recommended 150 minutes a week of moderate intensity exercise. High intensity interval training (HIIT) is emerging as an alternative as it delivers similar or better gains than moderate intensity exercise in less time. Recently, we published that a 3-day-a-week, 10-minute HIIT regimen in aged mice not only reduces frailty, but leads to both strength and endurance benefits. In addition, our preliminary data demonstrate significant changes in microRNA (miRNA) profiles. Despite the potential of short session HIIT to improve functional capacity and lead to better adherence, the modality has not been tested in individuals 65-85 years of age, and in particular, frail individuals. The goals of this proposal are to: 1) investigate the feasibility of recruiting and administering short session HIIT to frail, pre-frail, and non-frail older veterans and 2) to characterize the physical performance benefits and serum microRNA (miRNA) profiles in those participants. To accomplish our goals we will administer a short session HIIT regimen totaling only 10- minutes, 3-days-a-week for 3 months, using recumbent exercise cycles, to 65-85 year-old participants. We will also utilize next generation RNA-sequence technology to assess HIIT impacts upon microRNA profiles in serum samples. We anticipate our project will demonstrate the feasibility of administering short session HIIT to older individuals, including vulnerable frail and pre-frail populations as well as demonstrate the ability to collect and analyze serum miRNA profiles. The advantages to this program are the ability to maintain or build muscle mass and improve aerobic conditioning, especially in older HIIT enhances physical performance and reduces frailty during aging. patients where frailty and sarcopenia are so prevalent. This pilot project will therefore lay the foundation for future clinical trials that further explore the utility of HIIT to prevent or delay the onset of frailty in larger cohorts, and ultimately lead to the enhancement of functional capacity and quality of life in our aging veteran populations.