CORE--INSTRUMENTATION/SUPPORT FACILITY

核心设施旨在为该计划的所有或大多数参与者使用的多个技术领域提供支持。它提供了NMR光谱的能力，方便访问500，600和800 MHz仪器，使用Beckman XL-I ultracenthalge的分析ultracenthalgation，傅里叶变换红外光谱，肽合成和计算能力，包括三维结构显示，使用分子动力学模拟建模和数据库搜索。自两年多前开始提供赠款以来，这些设施都已建成并投入运作。虽然要求进行一些必要的升级，但认为核心研究中心基本上已经发展到一个很好的状态，如果配备适当的人员，完全有能力支持下一个赠款期拟议的研究。

The CORE facility is designed to provide support in several technical areas used by all or most of the participants in the program. It offers capabilities in NMR spectroscopy with facilitated access to 500, 600, and 800 MHz instruments, analytical ultracentrifugation using the Beckman XL-I ultracentrifuge, Fourier transform infrared spectroscopy, peptide synthesis, and computational capabilities that include three dimensional structural displays, modeling using molecular dynamics simulation, and database searching. In the period since the initiation of the grant a little more than two years ago, each of these facilities has been created and brought to operational status. While some desirable upgrades are requested, it is felt that the CORE has basically evolved to an excellent state, fully capable of supporting the research proposed for the next grant period if it is appropriately staffed.