DUAL HOT CELL SYSTEM AND AUXILLARY EQUIPMENT

本申请要求一种新的双热室系统，用于生产 用于核医学实验研究的放射性标记化学品， 尤其是正电子发射断层摄影术（PET）。新工具将 大大提高了合成放射化学计划的生产率 南加州大学，目前使用一个单一的，小的，热的细胞。的 所要求的热室将使南加州大学的教师能够充分利用我们的PET 扫描仪和放射化学专业知识，并将使我们能够提供一个 广泛的放射性化学品的研究计划，一些 现场和非现场调查人员，他们目前依赖现有的 南加州大学PET中心的实验室和成像设施。 现有的PET研究计划可容纳该领域的研究人员 肿瘤学、实验治疗学、神经科学和心血管 疾病目前项目的例子是开发放射性示踪剂 对于肿瘤中DNA合成的体内测量，表征 酒精中毒患者的神经受体状态及其相关因素的研究 血管性痴呆的病理生理学基础各种各样的无线电- 在实验动物模型中进行这些和未来所需的示踪剂 和人类实验对象需要一个高效的，最先进的生产 系统具有适当的质量控制、自动化和辐射安全。 所需的双热室系统将是实现这一目标的关键因素 目的，并为南加州大学的众多研究人员提供一种手段， 神经科学、肿瘤学、遗传医学和分子生物学课程 获得新的研究工具，以进行PHS支持的调查。

This application requests a new dual hot cell system for production of radiolabeled chemicals for experimental studies in nuclear medicine, especially positron emission tomography (PET). The new instrument will greatly enhance the productivity of the synthetic radiochemistry program at USC, which currently operates using a single, small, hot cell. The requested hot cells will enable faculty at USC to fully utilize our PET scanner and expertise in radiochemistry, and will permit us to provide a wide spectrum of radiochemicals to the research programs of a number of on-site and off-site investigators who currently depend on the existing laboratory and imaging facilities in the USC PET Center. The existing PET research program accommodates investigators in the fields of oncology, experimental therapeutics, neurosciences, and cardiovascular diseases. Examples of current projects are development of radio-tracers for in vivo measurement of DNA synthesis in tumors, characterization of neuroreceptor status in alcoholic, and investigation of the pathophysiological basis of vascular dementias. The wide array of radio- tracers required to conduct these and future in experimental animal models and human subjects necessitates an efficient, state-of-the-art production system with appropriate quality control, automation and radiation safety. The required dual hot cell system will be a key element in achieving this objective, and provide a means for numerous investigators in key USC programs in neuroscience, oncology, genetic medicine and molecular biology access to novel research tools to conduct PHS supported investigations.