Development of a Cellular and Molecular-Based Cancer Im*

基于细胞和分子的癌症 Im* 的开发

• 批准号: 6514556
• 负责人: Peter Stephen Conti
• 金额: $ 40万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-12 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6514556
• 关键词: cellular oncology; molecular oncology

DESCRIPTION: (provided by applicant) Over the last decade, medicine has undergone a profound and rapid change as a result of advances in cellular and molecular biology. Discoveries resulting from the sequencing of the human genome, advances in biotechnology and instrumentation, and a better understanding of tumor metabolism and physiology have contributed to this evolution as well. While we are rapidly approaching an understanding of the basic molecular Mechanisms of cancer, our ability to image this disease at its earliest of stages, differentiate cell characteristics in vivo, and rationally monitor the effects of new therapies remains an unrealized goal. Traditional anatomical imaging approaches in use today, such as radiography, CT and magnetic resonance imaging, play a fundamental role in clinical medicine, but do not provide the in vivo biochemical data needed to evaluate the metabolic and biochemical processes associated with cancer. Recent developments in magnetic resonance spectroscopy and positron emission tomography provide new dimensions to cancer imaging, offering unique ways to measure tumor biochemistry and the perturbations resulting from therapy. These technologies have not, however, realized their potential with respect to imaging the molecular basis of disease. This can only be achieved through integration of the advances made in several fields, including molecular and cellular biology, chemistry, physics, pharmacology, engineering and computer sciences. The University of Southern California and the Norris Comprehensive Cancer Center have developed a application to design a molecular and cellular-based cancer Imaging Center. The concept of developing a U.S.C./Norris Cancer Imaging Center has attracted productive teams of scientists committed to its successful implementation. Renowned experts in basic science and medicine are committed to creating the collaborative relationships necessary to achieve the ultimate goal of this initiative, which is to improve the care of cancer patients through translation of advances in cancer research to the clinical setting. We envision that the introduction of this NCI sponsored Cancer Imaging Center will foster the integration of advances in biomedical imaging and basic science, leading to improvements in diagnosis and staging of cancer, guidance of therapy and monitoring of treatment by providing more useful and relevant physiological and biochemical information that is available today. The University and Norris Cancer Center are committed to development of the USC Cancer Imaging Center. As noted in the application, the Cancer Center is making a substantial financial commitment to the proposed Imaging Center, including partial funding of a Post-doctoral Research Fellow and matching pilot/project funding.

描述：（申请人提供） 在过去的十年里，医学经历了深刻而迅速的变化， 这是细胞和分子生物学进步的结果。发现导致 从人类基因组测序，生物技术的进步， 更好地了解肿瘤代谢和生理学 也促进了这一演变。当我们快速接近 了解癌症的基本分子机制，我们的能力， 对这种疾病早期阶段进行成像，分化细胞 体内特性，合理监测新疗法的效果 仍然是一个未实现的目标。使用中的传统解剖成像方法 今天，如放射线照相术，CT和磁共振成像， 在临床医学中的基本作用，但不提供体内 评估代谢和生化过程所需的生化数据 与癌症有关。磁共振波谱学的最新进展 和正电子发射断层摄影术为癌症成像提供了新的维度， 提供了独特的方法来测量肿瘤的生物化学和扰动， 是治疗的结果然而，这些技术并没有实现其 在疾病的分子基础成像方面的潜力。这可以 只有通过整合多个领域取得的进展才能实现， 包括分子和细胞生物学，化学，物理学，药理学， 工程和计算机科学。南加州大学和 诺里斯综合癌症中心开发了一个应用程序， 一个基于分子和细胞的癌症成像中心。的概念 开发U.S.C./诺里斯癌症成像中心吸引了富有成效的 科学家团队致力于其成功实施。知名 基础科学和医学专家致力于创造 合作关系，以实现这一目标的最终目标。 该倡议旨在通过以下措施改善癌症患者的护理 将癌症研究的进展转化为临床环境。我们 设想NCI赞助的癌症成像中心的引入 将促进生物医学成像和基础医学的融合 科学，导致癌症诊断和分期的改进，指导 通过提供更有用和相关的信息， 生理学和生化学的信息。的 大学和诺里斯癌症中心致力于南加州大学的发展 癌症影像中心。如申请书中所述，癌症中心是 对拟议的成像中心作出实质性的财务承诺， 包括博士后研究员的部分资助和匹配 试点/项目供资。