Development of a Cellular and Molecular-Based Cancer Im*

描述：(申请人提供) 在过去的十年里，医学作为一种 细胞和分子生物学进步的结果。由此产生的发现 从人类基因组测序，生物技术的进步和 仪器，以及对肿瘤代谢和生理学的更好理解 也对这种演变做出了贡献。当我们迅速接近的时候 了解癌症的基本分子机制，我们有能力 想象这种疾病最早的阶段，分化细胞 体内特征，合理监测新疗法的效果 仍然是一个未实现的目标。使用中的传统解剖成像方法 如今，如放射成像、CT和磁共振成像，发挥着重要作用 在临床医学中发挥基础性作用，但不能提供体内 评估代谢和生化过程所需的生化数据 与癌症有关。磁共振波谱学的最新进展 正电子发射断层扫描为癌症成像提供了新的维度， 提供测量肿瘤生化和扰动的独特方法 是由治疗引起的。然而，这些技术还没有实现它们的 在成像疾病的分子基础方面的潜力。这可以 只有通过整合在几个领域取得的进展才能实现， 包括分子和细胞生物学、化学、物理学、药理学、 工程学和计算机科学。南加州大学和 诺里斯综合癌症中心已经开发了一款应用程序来设计 一个基于分子和细胞的癌症成像中心。这一概念 南卡罗来纳州/诺里斯癌症成像中心的开发吸引了富有成效的 科学家团队致力于它的成功实施。著名的 基础科学和医学专家致力于创造 实现此目标的最终目标所需的协作关系 倡议，即通过以下方式改善对癌症患者的护理 将癌症研究的进展转化为临床环境。我们 设想NCI赞助的癌症成像中心的引入 将促进生物医学成像和基础医学领域的进展相结合 科学，导致癌症诊断和分期的改进，指导 通过提供更有用和相关的治疗和监测治疗 今天可用的生理和生化信息。这个 大学和诺里斯癌症中心致力于南加州大学的发展 癌症影像中心。如申请表中所示，癌症中心是 向拟建的影像中心投入大量资金， 包括部分资助一名博士后研究员和匹配 试点/项目资金。

DESCRIPTION: (provided by applicant) Over the last decade, medicine has undergone a profound and rapid change as a result of advances in cellular and molecular biology. Discoveries resulting from the sequencing of the human genome, advances in biotechnology and instrumentation, and a better understanding of tumor metabolism and physiology have contributed to this evolution as well. While we are rapidly approaching an understanding of the basic molecular Mechanisms of cancer, our ability to image this disease at its earliest of stages, differentiate cell characteristics in vivo, and rationally monitor the effects of new therapies remains an unrealized goal. Traditional anatomical imaging approaches in use today, such as radiography, CT and magnetic resonance imaging, play a fundamental role in clinical medicine, but do not provide the in vivo biochemical data needed to evaluate the metabolic and biochemical processes associated with cancer. Recent developments in magnetic resonance spectroscopy and positron emission tomography provide new dimensions to cancer imaging, offering unique ways to measure tumor biochemistry and the perturbations resulting from therapy. These technologies have not, however, realized their potential with respect to imaging the molecular basis of disease. This can only be achieved through integration of the advances made in several fields, including molecular and cellular biology, chemistry, physics, pharmacology, engineering and computer sciences. The University of Southern California and the Norris Comprehensive Cancer Center have developed a application to design a molecular and cellular-based cancer Imaging Center. The concept of developing a U.S.C./Norris Cancer Imaging Center has attracted productive teams of scientists committed to its successful implementation. Renowned experts in basic science and medicine are committed to creating the collaborative relationships necessary to achieve the ultimate goal of this initiative, which is to improve the care of cancer patients through translation of advances in cancer research to the clinical setting. We envision that the introduction of this NCI sponsored Cancer Imaging Center will foster the integration of advances in biomedical imaging and basic science, leading to improvements in diagnosis and staging of cancer, guidance of therapy and monitoring of treatment by providing more useful and relevant physiological and biochemical information that is available today. The University and Norris Cancer Center are committed to development of the USC Cancer Imaging Center. As noted in the application, the Cancer Center is making a substantial financial commitment to the proposed Imaging Center, including partial funding of a Post-doctoral Research Fellow and matching pilot/project funding.