Ultra-High Resolution CT Specimen Scanner for In Vitro Applications

适用于体外应用的超高分辨率 CT 样本扫描仪

• 批准号: 7795629
• 负责人: Peter Stephen Conti
• 金额: $ 49.16万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7795629
• 关键词: Animals; Area; Assimilations; Automobile Driving; Award; Biochemistry; Clinical Research; Complement; Computer software; Coupled; Dentistry; Developmental Biology; Developmental Process; Devices; Discipline; Disease; Funding; Housing; Image; In Vitro; Institutes; Investigation; Laboratories; Laboratory Animals; Licensing; Magnetic Resonance; Medical Imaging; Medicine; Molecular Biology; National Center for Research Resources; Nuclear; Operative Surgical Procedures; Optics; Organ; Pathology; Positron-Emission Tomography; Productivity; Public Health; Radio; Request for Proposals; Research; Research Personnel; Resolution; Sampling; Scanning; Science; Specimen; System; Transgenic Mice; Ultrasonography; United States National Institutes of Health; Work; X-Ray Computed Tomography; bone; data acquisition; in vivo; instrument; instrumentation; miniaturize; molecular imaging; mouse model; operation; optical imaging; portability; public health relevance; soft tissue; ultra high resolution

DESCRIPTION (provided by applicant): Recent advances in the instrumentation for medical imaging have produced miniaturized versions of x-ray, optical, radio nuclear, ultrasound, and magnetic resonance scanners for studies in small laboratory animals. This, coupled with increasingly sophisticated transgenic mouse models, is driving a revolution in the investigation of disease and developmental processes in vivo at the whole-animal level. High resolution in vitro scanning capabilities complement these advances, allowing, for example, assessment of structural detail of dense organs such as bone as well as soft tissues. In this proposal, we are requesting funding for an ultra-high resolution (0.5-10 micron) CT specimen scanner to expand our in vitro imaging capabilities at the USC. During the last several years, a Molecular Imaging Center has been established at USC with support from multiple awards from the NCRR and other NIH Institutes. The requested device, a SCANCO u50CT, will be housed and operated in the Center's Molecular Imaging Laboratory, where it will complement other shared-use devices purchased with previous awards from the NCRR, including small-animal PET, CT, ultrasound, and optical imaging systems. The device has superior features for ultra-high resolution imaging and extensive software support, which will make it applicable to a broad range of disciplines. The instrument chosen also has numerous features conducive to efficient operation, including, DICOM compatibility (essential for assimilation into our developing animals PACS system), portability within the laboratory, and a carousel imaging station that allows rapid multi-sample data acquisition. USC already owns a license for the software package, reducing the requested support from NCRR. The requested device will be used by investigators in the fields of medicine, surgery, pathology, biochemistry/molecular biology, dentistry and material sciences. Addition of the requested instrument will increase the productivity of assembled PHS-funded investigators who are working in various areas of medicine, dentistry and developmental biology. The discoveries and advancements made by these investigators will ultimately have a direct positive impact on public health. PUBLIC HEALTH RELEVANCE: We are requesting a high-resolution micro-computed tomography (microCT) scanner for quantitative x-ray of in vitro specimens. It is an essential imaging unit that will satisfy all of the required research imaging objectives because of the diverse needs of the user group. Research conducted using this instrument, may move forward into clinical research trials with great potential public health implications.

描述（由申请人提供）：医学成像仪器的最新进展已经产生了用于小型实验室动物研究的X射线、光学、放射性核、超声和磁共振扫描仪的小型化版本。这一点，加上日益复杂的转基因小鼠模型，正在推动一场革命的疾病和发育过程的调查在体内在整个动物的水平。高分辨率的体外扫描功能补充了这些进步，例如，允许评估致密器官（如骨骼和软组织）的结构细节。在这项提案中，我们要求为超高分辨率（0.5-10微米）CT标本扫描仪提供资金，以扩大我们在南加州大学的体外成像能力。 在过去的几年中，在NCRR和其他NIH研究所的多个奖项的支持下，南加州大学建立了一个分子成像中心。申请的设备SCANCO u 50 CT将在该中心的分子成像实验室中安装和运行，在那里它将补充从NCRR购买的其他共享使用设备，包括小动物PET，CT，超声和光学成像系统。该设备具有超高分辨率成像的上级功能和广泛的软件支持，这将使其适用于广泛的学科。所选仪器还具有许多有助于高效操作的功能，包括DICOM兼容性（对于同化到我们开发的动物PACS系统中至关重要），实验室内的便携性，以及允许快速多样本数据采集的旋转式成像站。南加州大学已经拥有软件包的许可证，减少了NCRR的支持请求。 申请的器械将由医学、外科、病理学、生物化学/分子生物学、牙科和材料科学领域的研究者使用。增加所需的仪器将提高组装的公共卫生服务资助的研究人员谁是在医学，牙科和发育生物学的各个领域工作的生产力。这些研究人员的发现和进步最终将对公共卫生产生直接的积极影响。 公共卫生相关性：我们正在申请高分辨率微型计算机断层扫描（microCT）扫描仪，用于体外标本的定量X射线。它是一个必不可少的成像单元，将满足所有所需的研究成像目标，因为用户群体的不同需求。使用该仪器进行的研究可能会进入具有巨大潜在公共卫生影响的临床研究试验。

项目成果

A geometric morphometric approach to investigate primate proximal phalanx diaphysis shape.

• DOI: 10.1002/ajpa.24460
• 发表时间: 2022-03
• 期刊: AMERICAN JOURNAL OF BIOLOGICAL ANTHROPOLOGY
• 作者: Wennemann, Sophie E.;Lewton, Kristi L.;Orr, Caley M.;Almecija, Sergio;Tocheri, Matthew W.;Jungers, William L.;Patel, Biren A.
• 通讯作者: Patel, Biren A.