Assessment of LV volume & function by real time 3-dimensional echocardiograph

左心室（LV）容积很重要 心脏病患者的预后指标。尽管几 方法可以评估LV容量，大多数具有重要的内在 局限性。实时三维超声心动图（RT 3D 回波）是一种能够瞬时采集 体积图像。本研究旨在验证快速LV 使用RT 3D回波进行体积计算，并确定其 对心脏病患者有帮助。从11只羊身上取出的心脏， 离体研究。在左心室内放置了一个乳胶球囊， 心室并填充已知量的盐水溶液（n=52; 范围：38-120 ml）。使用RT 3D回波采集的体积图像 与实际左心室容积进行比较。此外，4个法线 21例心脏病患者接受了磁共振成像 (MRI)和实时三维超声心动图在离体动物中 在研究中，观察到实际LV 与RT 3D超声计算的体积比较（r=0.99; y=1.31+0.98 x; SEE=2.2 ml）。在人类研究中， MRI计算的LV体积之间存在相关性 与RT 3D回波的相关系数r=0.91; y=20.1+0.71x; SEE=28 ml。LV MRI获得的体积大于 RT 3D回波（126+/-83 vs. 110+/-65 ml; p=0.002），可能是由于 MRI采集期间的心率低于 在RT 3D超声检查期间（62+/-11 vs. 79+/-16 心跳/分钟; p=0.0001）。观察者内和观察者间变异性分析 在LV测量中显示出很强的一致性指数 RT 3D echo的体积。因此，LV容量测量 RT 3D回波准确且可重现。这项技术扩展了 使用超声对患者进行非侵入性评估 并提供了一种新的工具， 心血管疾病的调查研究。

Left ventricular (LV) volumes are important prognostic indices in patients with heart disease. Although several methods can evaluate LV volumes, most have important intrinsic limitations. Real-time three-dimensional echocardiography (RT3D echo) is a novel technique capable of instantaneous acquisition of volumetric images. This study was undertaken to validate rapid LV volume calculations with RT3D echo and to determine their usefulness in cardiac patients. Hearts explanted from 11 sheep were studied ex vivo. A latex balloon was positioned within the left ventricle and filled with known amounts of saline solution (n=52; range: 38-120 ml). Volumetric images acquired with RT3D echo were compared to the actual LV volumes. In addition, 4 normals and 21 cardiac patients underwent magnetic resonance imaging (MRI) and RT3D echo on the same day. In the ex vivo animal studies, a strong correlation was observed between the actual LV volumes and those calculated with RT3D echo (r=0.99; y=1.31+0.98 x; SEE=2.2 ml). In the human studies, a strong correlation was found between LV volumes calculated with MRI and with RT3D echo (r=0.91; y=20.1+0.71x; SEE=28 ml). LV volumes obtained with MRI were greater than those obtained with RT3D echo (126+/-83 vs. 110+/-65 ml; p=0.002), probably due to the fact that the heart rate during MRI acquisition was lower than that during RT3D echo examination (62+/-11 vs. 79+/-16 beats/min; p=0.0001). Analysis of intra and interobserver variability showed strong indices of agreement in the measurement of LV volumes with RT3D echo. Thus, LV volume measurements with RT3D echo are accurate and reproducible. This technique expands the use of ultrasound for the non-invasive evaluation of patients with heart conditions and provides a new tool for the investigational study of cardiovascular disease.