Discovering The Effect of alpha-actinin-3 Deficiency on Muscle Adaptations to Exercise Training in Humans

蛋白质α-辅肌动蛋白-3在快肌纤维中表达。一种常见的基因变异导致α-辅肌动蛋白-3完全缺乏，这已被证明会影响运动成绩。先前已经产生了小鼠模型，以证明α-辅肌动蛋白-3缺乏导致快速肌纤维向缓慢、更有效的肌纤维的显著转变。本项目将展示α-辅肌动蛋白-3缺乏对运动训练前后人体肌肉特性的影响。其成果将包括个性化健康建议和设计老龄化预防计划的主要应用。

The protein alpha-actinin-3 is expressed in fast muscle fibres. A common gene variant results in complete deficiency in alpha-actinin-3 that has been shown to influence athletic performance. A mouse model has been previously generated to demonstrate that alpha-actinin-3 deficiency results in a significant shift in fast muscle fibres, towards the slow, more efficient muscle fibres. This project will demonstrate the effects of alpha-actinin-3 deficiency on the characteristics of human muscle pre and post exercise training. Outcomes will include major applications for personalising health recommendations and in designing preventative programs for ageing.