CORE--CELL BIOLOGY

该计划项目代表了一组具有凝聚力的实验室和 拥有共同目标和战略的调查人员旨在 将基因转移到祖细胞和分化细胞。这些 实验室也同样需要几种技术，例如 基因转移载体的创建和产生的数据的分析 通过基因转移研究。细胞生物学核心设施旨在 为这组调查人员提供各种成像和 显示载体与靶细胞相互作用的检测方法， 载体编码转基因的表达及其生理意义 转基因表达的影响。为此，细胞生物学 核心设施维护最先进的荧光设备 检测、最佳过滤器和记录设备 Brightfield和荧光图像采集，并促进 访问其他医疗中心资源，如组织学、 超微结构和共焦设备。此外，工作人员 在细胞生物学核心设施方面有广泛的培训 各种细胞学和组织学技术，并将致力于 将这些资产提供给 参与项目和试点。这个核心设施的目标是 以及与该计划相关的其他核心设施 项目将在整个研究过程中得以实现 努力要大于各部分之和。

This Program Project represents a cohesive group of laboratories and investigators that share common goals and strategies aimed at transferring genes to progenitor and differentiated cells. These laboratories also share a need for several techniques such as the creation of gene transfer vectors and the analysis of data generated by gene transfer studies. The Cell Biology Core Facility aims to provide this group of investigators with a variety of imaging and detection methods to show interaction of vectors with target cells, expression of vector-encoded transgenes, and the physiological impact of transgene expression. Toward this end, the Cell Biology Core FaCility maintains state-of-the-art equipment for fluorescence detection, optimal filters and documentation equipment for brightfield and fluorescence image acquisition, and facilitated access to additional medical Center resources such as histological, ultrastructural, and con focal facilities. Furthermore, the staff of the Cell Biology Core Facility has extensive training in a variety of cytological and histological techniques and will dedicate time and resources to make those assets available to the participating Projects and Pilots. The goal of this Core Facility as well as the other core facilities associated with the Program Project will be realized in making the whole of this research endeavor greater than the sum of its parts.