DEVELOPMENT OF RAPID EFFECTIVE PROTEIN IDENTIFICATION ALGORITHMS "PROFOUND"

我们继续完善蛋白质纯化软件 一个叫做“ProFound”的程序，它利用了大量的信息， 光谱肽图谱，以确定其序列 存储在一个可公开访问的数据库中。 这个程序， 这是由张文竹（我们的研究资源的成员）撰写的 可以在万维网上公开获取 (http//www.rockefeller.edu）。该程序是唯一的蛋白质 目前可用的识别软件， 概率标准来对蛋白质鉴定调用进行排序。 在 此外，它允许识别蛋白质的混合物， 使用客观标准。 ProFound正被科学家们广泛使用 世界各地 一份描述该软件的文件目前在 准备.

We have continued to refine a protein idenfication software routine called "ProFound", which makes use of information from mass spectrometric peptide maps to identify proteins whose sequence is stored in one of the publicly accessible databases. This program, which was written by Wenzhu Zhang (a member of our Research Resource) is publicly available over the World Wide Web (http//prowl-sgi.rockefeller.edu). The program is the only protein identification software currently available that uses robust probability criteria to rank the protein identification calls. In addition, it allows for the identification of mixtures of proteins using objective criteria. ProFound is being widely used by scientists all over the world. A paper describing the software is currently in preparation.