INHIBITORS OF OPPORTUNISTIC INFECTION: AIDS RELATED PNEUMONIA
INHIBITORS OF OPPORTUNISTIC INFECTION: AIDS RELATED PNEUMONIA
批准号:
6258801
负责人:
THOMAS J DELIA
金额:
$0.06万
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-06-01 至 1999-11-30
中文摘要
目前的研究涉及芳基醚的制备,
潜在的生物活性化合物。 其中一项研究涉及
作为肺孢子虫抑制剂的苯基嘧啶基醚的形成
卡氏肺炎抑制剂。 这项工作已经导致了几个温和的
活性化合物,这是最近发表的。 略
还发现不同的结构具有初步的
抗肿瘤活性。 现在确定其重要性还为时过早。
这些结果。 有时我们会遇到一些分子
证明与我们有限的MS能力兼容。 为了
为了获得更好的结构数据,我们必须依靠替代电离
我们的家庭机构没有这种方法。
英文摘要
Current research involves the preparation of aryl ethers as
potential bio-active compounds. One line of research involves the
formation of phenyl pyrimidyl ethers as inhibitors of Pheumocystis
carinii pneumonia inhibitors. This work has led to several moderately
active compounds and this has recently been published. Slightly
different structures have also been found to possess preliminary
antitumor activity. It is too early to determine the significance of
these results. From time to time we encounter molecules that do not
prove compatible with our own limited MS capability. In order to
obtain better structural data we must rely on alternative ionization
methods not available at our home institution.
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INHIBITORS OF OPPORTUNISTIC INFECTION: AIDS RELATED PNEUMONIA
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批准号:6248363
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项目类别:
-
资助金额:$0.46万
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财政年份:1997
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负责人:THOMAS J DELIA
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依托单位:
SYNTHESIS OF ANTIFOLS AND MECHANISM-BASED INHIBITORS
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批准号:3437247
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项目类别:
-
资助金额:$6.79万
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财政年份:1987
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负责人:THOMAS J DELIA
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依托单位:
海外基金