SUBPHTHALOCYANINE & SUBTRIAZAPORPHINE CHEMISTRY

亚酞菁(SubPc)是含硼的大环化合物，具有 三个异吲哚单元，而不是在 酞菁类化合物。使用由以下人员开发的扩环反应 Kobayashi等人，SubPC可以作为 不对称酞菁化合物的合成。不对称 目前，人们正在研究几种酞菁类化合物 用途，包括用作非线性光学染料和AS 催化剂。我们对开发非对称PC感兴趣 在某些癌症的治疗中作为光动力制剂的研究。至 为此，我们合成了几个化合物并进行了结构表征 新的亚磷胆碱和相关的三氮杂吗啡。特别值得关注的是 含有外周分子识别位点的PC。这样的约束 在抗肿瘤药物的开发中，位点可能是重要的。低 分辨率和高分辨率FAB-MS是研究 我们产品的特性。

Subphthalocyanines (SubPcs) are boron-containing macrocycles with three isoindoline units, instead of the four found in the phthalocyanines. Using the ring-expansion reaction developed by Kobayashi, et al., the SubPcs can serve as precursors for the synthesis of unsymmetrical phthalocyanines. Unsymmetrical phthalocyanines are currently being studied for a number of applications, including use as nonlinear optical dyes and as catalysts. We are interested in developing unsymmetrical Pcs for study as photodynamic agents in the treatment of certain cancers. To this end we have synthesized and structurally characterized several new SubPcs and related subtriazaporphines. Of special interest are Pcs that contain peripheral molecular recognition sites. Such binding sites could be important in the development of anti-tumor agents. Low resolution and high resolution FAB-MS are important tools in the characterization of our products.