DIABETES PREVENTION TRIAL--TYPE I DIABETES

这项全国性研究旨在确定有患I型胰岛素依赖型糖尿病（IDDM）风险的个体。密歇根大学将作为这个国家多中心研究的附属中心，在糖尿病预防试验-1型糖尿病（DPT-1）中筛选患者，进行耐受性试验并执行治疗方案的各个方面。这些被确定的个体将被邀请参加一项国家对照随机试验，以确定胰岛素免疫是否可以在5年内预防IDDM的发展。本研究的假设是胰岛素免疫可以预防β细胞损伤，从而预防IDDM的发展。研究人员将隶属于科罗拉多大学芭芭拉戴维斯儿童糖尿病中心，该中心是该研究的临床协调中心，已获得美国国立卫生研究院的批准。

This national study is designed to identify individuals who are at risk of developing Type I Insulin Dependent Diabetes Mellitus (IDDM). The University of Michigan will act as an Affiliated Center in this national multicenter study to screen patients, perform tolerance test and conduct various aspects of the Treatment Protocols in the Diabetes Prevention Trial-Type 1 Diabetes (DPT-1). Those individuals identified will be invited to participate in a national controlled, randomized trial to determine if immunization with insulin can prevent development of IDDM within 5 years. The hypothesis of this study is immunization with insulin may prevent beta cell damage and therefore development of IDDM. The investigators will be affiliated with the University of Colorado Barbara Davis Center for Childhood Diabetes, a clinical coordinating center for this study, which has been approved by the National Institutes of Health.