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TEMOZOLOMIDE & BCNU FOR ANAPLASTIC GLIOMAS

TEMOZOLOMIDE & BCNU FOR ANAPLASTIC GLIOMAS
替莫唑胺
批准号：
6263693
负责人：
HARRY S GREENBERG
金额：
$0.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6263693
关键词：
astrocytoma carmustine clinical research combination chemotherapy glioma human subject human therapy evaluation neoplasm /cancer chemotherapy temozolomide

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中文摘要
翻译
一项多中心北美脑肿瘤委员会联合IV BCNU和口服替莫唑胺治疗恶性星形细胞瘤的II期试验。这些药物的复发耐药机制是高水平的o6烷基鸟嘌呤转移酶。BCNU将用于消耗这种酶，理论是替莫唑胺在细胞酶水平较低时更有效。将研究两组患者：1.原发性治疗失败（手术、放疗和化疗）后复发的胶质母细胞瘤；2.手术后未接受放疗的间变性胶质瘤和混合间变性胶质瘤。
英文摘要
A phase II multicenter North American Brain Tumor Board Consortium trial to treat malignant astrocytomas with the combination of IV BCNU and oral temozolomide. The mechanism of denovo drug-resistance for these drugs is high levels of the enzyme O 6 alkylguanine transferase. BCNU will be used to deplete this enzyme with the theory that temozolomide will be more effective with lower cellular levels of the enzyme. There will be two patient groups studied 1.) recurrent glioblastoma after primary treatment failure (surgery, radiation and chemotherapy) and 2.) anaplastic gliomas and mixed anaplastic gliomas following surgery without prior radiation therapy.
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MARIMASTAT IN PATIENTS W/ GLIOBLASTOMA MULTIFORME OF GLIOSARCOMA
MARIMASTAT IN PATIENTS W/ GLIOBLASTOMA MULTIFORME OF GLIOSARCOMA
TEMOZOLOMIDE & BCNU FOR ANAPLASTIC GLIOMAS
MARIMASTAT IN PATIENTS W/ GLIOBLASTOMA MULTIFORME OF GLIOSARCOMA
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