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ADRENERGIC RESPONSES AND INSULIN RESISTANCE IN GERIATRIC HYPERTENSION

ADRENERGIC RESPONSES AND INSULIN RESISTANCE IN GERIATRIC HYPERTENSION
老年高血压的肾上腺素能反应和胰岛素抵抗
批准号:
6297198
负责人:
Mark A Supiano
金额:
$0.02万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-12-01 至 1999-11-30

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项目成果

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中文摘要
翻译
我们以前的研究结果支持一个假设,即老年人的高血压部分与年龄相关的SNS活动增加有关,同时伴有正常下调α-肾上腺素能反应的能力减弱。 将在本建议中描述的研究中测试的一般假设是,在具有增加的SNS活性和代谢胰岛素抗性的老年高血压患者中,也存在对胰岛素的血管扩张作用的抗性,其干扰α-肾上腺素能反应性的下调。"
英文摘要
Results from our previous studies support an hypothesis that hypertension in older humans is related, in part, to an age-related increase in SNS activity coupled with diminished ability to normally down-regulate a-adrenergic responsiveness. The general hypothesis which will be tested in the studies described in this proposal is that in older hypertensive humans with increased SNS activity and metabolic insulin resistance, there is also resistance to insulin's vasomotor effects which interferes with down-regulation of a-adrenergic responsiveness. "
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Cardiovasomobility Research Training Program
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    10439465
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  • 财政年份:
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海外基金