VITAMIN E IN TREATMENT OF IGA NEPHROPATHY IN CHILDREN

IGA肾病是一种肾脏疾病，会导致血液和尿液中蛋白质的流失，甚至在儿童时期就会导致严重的肾衰竭。不幸的是，尽管已经尝试了许多药物，但还没有得到证实的治疗IgA肾病的方法。维生素E是一种天然存在的物质，具有“抗氧化”作用，这意味着它可以防止某些被称为“自由基”的含氧物质造成的损害。基于对实验性IgA肾病大鼠的研究，一些研究人员认为，给患有IgA肾病的儿童服用维生素E可能会减少或防止肾脏疤痕的发展，从而降低发生肾衰竭的机会。这是一项多中心研究，在这项研究中，患有活检证实的临床轻度IgA肾病的儿童和年轻人将被随机分为两年，每天接受一次维生素E或安慰剂。研究中的受试者将被跟踪观察肾功能、血尿(尿血)和蛋白尿的变化，以了解维生素E是否是治疗IgA肾病的有效方法。

IgA nephropathy is a disease of the kidneys which leads to loss of blood and protein in the urine and can lead to severe kidney failure even when it begins in childhood. Unfortunately, there is no proven treatment for IgA nephropathy, although numerous medications have been tried. Vitamin E is a naturally occurring substance that has "anti-oxidant" effects, meaning that it can protect against damage caused by certain oxygen-containing substances called "free radicals. Based upon studies in rats with experimental IgA Nephropathy, some researchers feel that giving Vitamin E to children with IgA Nephropathy may reduce or prevent the development of kidney scarring and therefore reduce the chances of developing kidney failure. This is a multicenter study in which children and young adults with biopsy-proven, clinically mild IgA Nephropathy will be randomized to receive either Vitamin E or placebo once daily for two years. Subjects in the study will be followed for changes in kidney function, hematuria (blood in the urine), and proteinuria to learn whether Vitamin E is an effective treatment for IgA Nephropathy.