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HOMOLOGY MODELING OF PROTEIN TYROSINE PHOSPHATASES

HOMOLOGY MODELING OF PROTEIN TYROSINE PHOSPHATASES
蛋白质酪氨酸磷酸酶的同源建模
批准号：
6263653
负责人：
MARK A SAPER
金额：
$0.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6263653
关键词：
bacteria bacterial proteins chemical models computer simulation molecular biology information system protein structure function protein tyrosine phosphatase structural biology

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中文摘要
翻译
我们将收集所有可用的PTPases以及相关蛋白质的数据库，然后使用多序列比对程序（如pileup）来确定最佳比对。 从比对中获得的同源谱将与已知晶体结构的生化数据和信息合并，以研究磷酸酶的结构和功能关系以及底物特异性。
英文摘要
We will assemble a database of all available PTPases as well as related proteins and then use mulitple sequence alignment programs (such as pileup) to determine an optimal alignment. The homology profile obtained from the alignment will be merged with the biochemical data and information of the known crystal structures in order to study structure and function relationship as well as substrate specificity of the phosphatases.
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Protein-protein interaction essential for bacterial growth and virulence
Protein-protein interaction essential for bacterial growth and virulence
Crystallization of outer membrane proteins for export of polysaccharide capsule
Crystallization of outer membrane proteins for export of polysaccharide capsule
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