REGIONAL CEREBRAL BLOOD FLOW CHANGES DURING ANTICIPATORY ANXIETY

本研究检查了局部脑血流量（RCBF）的变化， 主题在担心 该研究在以下部门进行： 约翰霍普金斯医学院的精神病学和放射学。 它 已经完成并在神经科学学会上发表 1997年10月25日至30日在新奥尔良举行的年度会议。 一篇文章在 准备在这个时候。 以下是方法的说明 初步分析。 正常人在压力之下也会产生忧虑。 它也构成了一个 病理性焦虑的一个重要组成部分， 压力源 我们检查了6例右心室的RCBF， 手正常的受试者，身心健康，没有 药物（平均年龄23岁，范围20-37岁，4名女性）。 他们经历了4 连续PET扫描（2次在中性思维期间，2次在担忧时），使用 015-H20作为示踪剂。 在听完之后， 听了一段2分钟的插花录音后， 到一个2分钟的磁带自我记录的担忧（例如，金融，疾病， 家庭、工作）。 在扫描过程中，受试者继续思考 在扫描结束之前，在磁带上听到的主题。 rCBF 中性思维时的RCBF与焦虑使用时的RCBF比较 MEDx和SPM 96。 显著性的标准是： 3.11（p<.001）和簇中至少25个置信度为2x2 x2 mm的体素。 在R尾状核中，在担忧期间发现rCBF相对增加， R壳核，R额下回，R顶下小叶，R 小脑蚓部、左小脑后叶和右脑桥。 结果 表明在忧虑时右半球和小脑激活。 它们与焦虑症患者R半球EEG活动增加一致。 强迫症患者的RCBF增加。

This study examined regional cerebral blood flow (RCBF) changes in subjects during worry. The study was conducted in the departments of Psychiatry and Radiology at The Johns Hopkins School of Medicine. It has been completed and was presented at the Society For Neuroscience annual meeting in New Orleans, October 25-30, 1997. An article is under preparation at this time. Following is a description of the methodology and preliminary analysis. Worrying occurs in normals under stress. It also constitutes an important ingredient of pathological anxiety where it occurs in absence of stressors. We examined the effect of worrying on RCBF in 6 right handed normal subjects, physically and mentally healthy and free of drugs (mean age 23 years, range 20-37, 4 female). They underwent 4 sequential PET scans (2 during neutral thoughts, 2 while worrying) using 015-H20 as tracer. Scans of neutral thoughts followed the listening to a 2-minute tape of flower arrangement, worries followed the listening to a 2 minute tape of self-recorded worries (ex. finance, illness in family, work). During scans, subjects continued to think about the topic previously heard on the tape until termination of the scan. RCBF during neutral thinking was compared with RCBF during worrying using MEDx and SPM96. Criteria for significance were: z-score > 3.11(p<.OOI)and at least 25 configuous 2x2x2mm voxels in the cluster. A relative increase in rCBF during worrying was found in the R caudate, R putamen, R inferior frontal gyrus, R inferior parietal lobule, R cerebellar vermis, L posterior cerebellar lobe and R pons. The results indicate right hemisphere and cerebellar activation while worrying. They are congruent with increased R hemisphere EEG activity in anxious individuals and increased RCBF seen in obsessive compulsive patients.