GENETIC & SOCIAL CO DETERMINANTS OF YOUTH BEHAVIORS

特应性疾病，如哮喘、过敏性鼻炎和特应性皮炎， 已知与比正常水平更高的抑郁症和 焦虑。 同样，一些行为障碍，包括抑郁、恐慌 精神障碍和社交焦虑与特应症的高发病率有关 体征和症状。目前尚不清楚这种特应性变态反应是否与 行为障碍是由于一种障碍导致另一种障碍的影响， 或者与环境或遗传共同风险因素有关。一 一种可用于确定方差比例的方法学 由于遗传或环境影响而产生的表型是双胞胎研究设计。 这项研究建议更全面地确定协方差的比例 由于共同的遗传或环境因素导致的特应性和 行为症状通过使用特应性的详细实验室测量，如 以及抑郁、焦虑、个性的几种自我报告测量 单合子(MZ)和双合子(DZ)的因素和保健行为 青春期的双胞胎。 研究的具体目的是：1)建立协方差 MZ和DZ双生子的特应性及情感和焦虑症状；2) 确定多大比例的协方差是由于遗传(A)，共享 (C)或非共有环境(E)因素；3)确定 因遗传(A)、共享(C)或 非共享环境(E)输入；以及4)建立以下各项的协方差 单合子和双合子患者的抑郁、焦虑与健康行为 (Dz)双胞胎。

Atopic disorders, such as asthma, allergic rhinitis and atopic dermatitis, are known to be associated with higher than normal rates of depression and anxiety. Likewise, several behavioral disorders, including depression, panic disorder and social anxiety, have been linked with high rates of atopic signs and symptoms. It is unclear whether this covariation of atopy with behavioral disorders is due to effects of one disorder causing the other, or to either an environmental or genetic common risk factor. One methodology useful for ascertaining the proportion of variance of a phenotype due to genetic or environmental effects is the twin study design. This study proposes to more fully determine the proportion of covariance due to common genetic or environmental factors underlying atopy and behavioral symptoms by use of detailed laboratory measurements of atopy, as well as several self report measures of depression, anxiety, personality factors and health care behaviors, in monozygotic (MZ) and dizygotic (DZ) adolescent twins. The Specific aims of the study are: 1) To establish the covariance of atopy and affective and anxiety symptoms in MZ and DZ twin pairs; 2) To determine what proportion of the co-variance is due to genetic (A), shared (C) or non-shared environmental (E) factors; 3) To establish the portion of variance in health care behaviors due to genetic (A), shared (C) or non-shared environmental (E) inputs; and 4) To establish the covariance of depression, anxiety and health behaviors in monozygotic (MZ) and dizygotic (DZ) twin pairs.