IMMUNOPATHOGENESIS & PREVENTION OF ASTHMA IN YOUNG CHILDREN

到目前为止，研究对象被认为是为了更好地了解幼儿哮喘的免疫发病机制。通过这个方案，我们在每个研究对象上获得了以下信息：1)体检，2)常见吸入剂和食物过敏原的刺激性过敏皮肤试验，3)献血检测血清IgE，嗜酸性粒细胞阳离子蛋白水平，以及详细的细胞免疫研究；4)病历编码。在这个为期5年的方案的第一年中，进展达到了招募的预期，并在免疫发病机制研究的初步数据中超出了预期。这些数据证实了1999年在几个不同的国家会议上提交的5份摘要。我们的计划是继续对其余研究对象进行这些免疫研究，以证实我们的初步发现，并确定这些早期免疫发现是否可以作为哮喘和过敏原敏化发展的预测因素。

Study subjects seen to date to better understand the immune pathogenesis of asthma in young children. Through this protocol, we have obtained the following on each study subject: 1) physical exam, 2) prick allergy skin testing to common inhalant and food allergens; 3) blood donation for serum IgE, Eosinophil Cationic Protein levels, and detailed cellular immune studies; and 4) medical records coding. Progress during the first year of this 5-year protocol has met expectations for recruitment, and exceeded expectations in preliminary data for immune pathogenesis studies. This data has substantiated 5 abstracts that have been accepted for presentation in 1999 at several different national meetings. Our plan is to continue these immune studies for the remainder of the study subjects to substantiate our preliminary findings, and to determine if these early immune findings may serve as predictors for the development of asthma and allergen sensitization.