COCAINE EXPOSED INFANTS & THEIR MOTHERS

这项研究是一项纵向、前瞻性的研究，旨在探讨胎儿在出生后头两年以及随访4年和6年期间与可卡因暴露的医学、环境和发育相关因素。对儿童的成长、认知、情绪、行为、语言和神经心理结果进行标准化评估。标准化问卷评估母亲的心理状态、应对方式、社会支持和暴力暴露。将对数据进行描述性评估，并通过一系列MANOVA/MANCOVA重复测量和分层多元回归来描述学龄前接触可卡因儿童的功能。最近对一岁婴儿的数据分析表明，在控制其他药物和混杂因素后，早期接触可卡因对婴儿智力发育结果和婴儿新奇表现以及早期神经行为和出生结果有显著影响。与对照组相比，使用可卡因的母亲具有更多的心理障碍，经历过更多的暴力，智力较低，照顾技能较差。每年大约有100-150名受试者入学。GCRC心理测量师为研究人员提供培训，并进行一些发育测试。

This study is a longitudinal, prospective investigation of the medical, environmental, and developmental correlates of fetal cocaine-exposure during the first two years of life and at follow-up ages of 4 and 6 years. Children are given standardized assessments of growth, cognitive, emotional, behavioral, language, and neuropsychological outcomes. Standardized questionnaires assess maternal psychological status, coping style, social supports, and exposure to violence. Data will be evaluated descriptively and through a series of MANOVAs/MANCOVAs with repeated measures and hierarchical multiple regression to describe the functioning of cocaine-exposed children at pre-school ages. Recent data analyses of infancts at one year of age has indicated that there are significant effects of early cocaine exposure, after control for other drugs and confounding factors, on infant mental development outcome and infant novelty performance as well as in early neurobehavioral and birth outcomes. Mothers who use cocaine are characterized as more psychologically disturbed, have experienced more violence, have lower intellectual ability, and poorer caretaking skills than controls. Approximately 100-150 subjects are enrolled each year. The GCRC psychometrist provides training to study personnel as well as conducting some of the developmental testing.