课题基金 / 基金详情

SAFETY, TOLERABILITY, AND ANTIRETROVIRAL ACTIVITY OF DMP 266

SAFETY, TOLERABILITY, AND ANTIRETROVIRAL ACTIVITY OF DMP 266
DMP 266 的安全性、耐受性和抗逆转录病毒活性
批准号：
6115459
负责人：
JAMES S KAHN
金额：
$3.1万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6115459
关键词：
AIDS therapy CD4 molecule antiAIDS agent antiviral agents clinical research combination chemotherapy drug resistance drug screening /evaluation genotype human subject human therapy evaluation indinavir outcomes research pharmacokinetics protease inhibitor reverse transcriptase inhibitors virus load

项目摘要

项目成果

JAMES S KAHN的其他基金

相似基金

相关文献

中文摘要
翻译
这是一项茚地那韦（蛋白酶抑制剂）的随机I/II期研究 和DMP 266（非核苷RT抑制剂）在CD 4细胞患者中的作用 100-500和病毒载量> 20，000拷贝/ML。治疗将 通过病毒载量、CD 4细胞变化和药代动力学评价。 的 本研究的目的是评估安全性、耐受性、抗病毒性、 DMP 266单独和与茚地那韦组合的活性， 通过基因型变化表征对DMP 266的抗性的发展 抵抗状态。
英文摘要
This is a randomized Phase I/II study of indinavir (protease inhibitor) and DMP266 (non-nucleoside RT inhibitor) in patients with CD4 cells between 100-500 and viral load> 20,000 copies/ML. Treatments will be evaluated by viral load, CD4 cell changes and pharmacokinetics. The objective of the study is to evaluate the safety, tolerability, anti-viral activity of DMP266 alone and in combination with indinavir and to characterize the development of resistance to DMP266 by genotypic change of resistant status.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Seek, Test, Treat and Retain strategies leveraging mobile health technologies
Adherence Improvement and Measurement- AIM- System. Challenge Topic 10-MH-101
Adherence Improvement and Measurement- AIM- System. Challenge Topic 10-MH-101
Randomized controlled trial embedded in an electronic health record
海外基金