ENDOCRINE ASPECTS OF HIV INFECTION

垂体、肾上腺和性腺激素的各种变化发生在 艾滋病毒感染，似乎与疾病的进展有关。病人 将被评估为垂体-肾上腺，性腺和生长激素轴， 特别注意昼夜节律和对 下丘脑释放激素。这项研究的目标是 描述与艾滋病毒感染相关的内分泌变化，并 将这些发现与疾病状态和免疫状态相关联。病人 也将在启动之前和之后进行前瞻性评估 抗病毒或免疫调节疗法(例如，蛋白酶抑制剂， 沙利度胺)，以评估这些药物对激素环境的影响。

Various alterations in pituitary, adrenal and gonadal hormones occur with HIV infection and appear to correlate with disease progression. Patients will be evaluated for pituitary-adrenal, gonadal and growth hormone axes, with specific attention to circadian rythmicity and response to hypothalamic-releasing hormones. The goal of this study is to characterize the endocrine changes associated with HIV infection and to correlate these findings with disease state and immune status. Patients will also be evaluated prospectively before and after initiation of potent antiviral or immunomodulatory therapy (e.g. protease inhibitors, thalidomide) to assess the impact of these agents on the hormonal milieu.