REGULATION OF PLASMA FATTY ACID OXIDATION DURING LOW & HIGH INTENSITY EXERCISE

在目前的研究中，我们检验了脂肪酸的假设 高强度运动时的氧化作用比运动时要少。 由于抑制长链脂肪而进行中等强度的运动 酸进入线粒体。六名志愿者以40%的速度锻炼 峰值耗氧量为60分钟，在80%时为30分钟 不同的场合。[1-13C]油酸，一种长链脂肪酸，以及 [1-14C]辛酸，一种中链脂肪酸，被注入用于 研究的持续时间。在治疗过程中注入了脂质和肝素 80%的运动可以防止血浆游离脂肪的预期下降 酸(FFA)浓度。血浆油酸和总游离脂肪酸利用率 在两个实验中是相似的。我们的数据表明，在 除了FFA利用率不佳外，脂肪酸氧化 在高强度运动中可能会受到限制，因为直接 抑制长链脂肪酸进入线粒体。

In the present study we examined the hypothesis that fatty acid oxidation is less during high-intensity exercise than during moderate-intensity exercise because of inhibition of long-chain fatty acid entry into the mitochondria. Six volunteers exercised at 40% peak oxygen consumption for 60 min and at 80% for 30 min on two different occasions. [1-13C]oleate, a long-chain fatty acid, and [1-14C]octanoate, a medium-chain fatty acid, were infused for the duration of the studies. Lipids and heparin were infused during exercise at 80% to prevent the expected decrease in plasma free fatty acid (FFA) concentration. Plasma oleate and total FFA availability were similar in the two experiments. Our data suggest that, in addition to sub-optimal FFA availability, fatty acid oxidation is likely limited during high-intensity exercise because of direct inhibition of long-chain fatty acid entry into mitochondria.